Advertisement

Blood–brain barrier and blood volume imaging of cerebral glioma using functional CT: a pictorial review

      Abstract

      We present five cases of cerebral glioma that illustrate the benefit of functional CT imaging of blood–brain barrier permeability and cerebral blood volume. Functional CT uses Patlak analysis of a single location dynamic sequence to extract physiological information that is useful clinically in the assessment of cerebral gliomas. Functional CT offers distinct advantages over other functional modalities, including clearer delineation of tumour, tumour grading, measurement of tumour activity and monitoring response to therapy.

      Keywords

      To read this article in full you will need to make a payment

      References

        • Miles K.
        • Dawson P.
        CT Permeability imaging: blood–brain barrier imaging.
        in: Miles K. Dawson P. Blomley M. Functional Computed Tomography. Oxford University Press, Oxford1997: 157-165
        • Groothius D.R.
        • Vriesendorp F.J.
        • Kupfer B.
        • et al.
        Quantitative measurements of capillary transport in human brain tumours by computed tomography.
        Ann Neurol. 1991; 30: 588-591
        • Terada T.
        • Nambu K.
        • Hoytani G.
        • et al.
        A method of quantitative measurement of cerebral vascular permeability using X-ray CT and iodinated contrast medium.
        Neuroradiology. 1992; 34: 290-296
        • Yeung W.T.I.
        • Lee T.
        • Del Maestro R.F.
        • Kozak R.
        • Brown T.
        In vivo CT measurement of blood–brain transfer constant of iopamidol in human brain tumours.
        J Neuro-Oncol. 1992; 14: 177-187
        • Bartolini A.
        • Gasparetto B.
        • Furlan M.
        • et al.
        Functional perfusion and blood–brain barrier permeability in the diagnosis of cerebral tumours by angio CT.
        Comput Med Imaging Graph. 1994; 18: 145-150
        • Aronen H.J.
        • Gazit I.E.
        • Louis D.N.
        • et al.
        Cerebral blood volume maps: comparison with tumour grade and histological findings.
        Radiology. 1994; 191: 41-51
        • Tofts P.S.
        • Kermode A.G.
        Measurement of the blood–brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts.
        Magn Reson Med. 1991; 17: 357-367
        • Su M.
        • Jao J.
        • Nalcioglu O.
        Measurement of vascular volume fraction and blood–tissue permeability constants with a pharmicokinetic model: studies in rat muscle tumours with dynamic Gd-DTPA enhanced MRI.
        Magn Reson Med. 1994; 32: 714-724
        • Pardo F.S.
        • Aronen H.J.
        • Kennedy D.
        • et al.
        Functional cerebral imaging in the evaluation and radiotherapeutic treatment planning of patients with malignant glioma.
        Int J Radiat Oncol Biol Phys. 1994; 30: 663-669
        • Wenz F.
        • Rempp K.
        • Heb T.
        Effect of radiation on blood volume in low-grade astrcytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging.
        Am. J. Radiol. 1996; 196: 187-193
        • Ford J.M.
        • Miles K.A.
        • Hayball M.P.
        • Bearcroft P.W.
        • Bleehan N.M.
        • Osbom C.S.
        A simplified technique for measurement of blood–barrier barrier permeability using CT: preliminary results and the effect of RMP-7.
        in: Faulkener K. Carey B. Crellin A. Harrison R.M. Quantitative Imaging in Oncology, Proceedings of the 19th LH Grey Conference. British Institute of Radiology London. 1996: 1-5
        • Roman-Golsdstein S.
        • Clunie D.A.
        • Stevens J.
        • et al.
        Osmotic blood–brain barrier disruption: CT and radionuclide imaging.
        Am J Neuroradiol. 1994; 15: 581-590