To evaluate lung abnormalities on thin-section computed tomographic (CT) scans in
patients with COVID-19 and correlate findings to duration of symptoms.
In total, 348 CT scans in 112 patients were classified according to the time after
the onset of the initial symptoms, namely stage-1 (0–4 days); stage-2 (5–9 days);
stage-3 (10–14 days); stage-4 (15–21 days); stage-5 (22–28 days); and stage-6 (＞28
days). Each lung lobe was evaluated for extent affected by ground-glass opacities
(GGO), crazy-paving pattern and consolidation, in five categories of percentual severity.
Summation of scores from all five lung lobes provided the total CT score (maximal
CT score, 25).
The predominant patterns of lung abnormalities were GGOs, crazy-paving pattern, consolidation
and linear opacities. The frequency of crazy-paving pattern, consolidation and linear
opacities peaked at stage-3 (62.7 %), stage-4 (75.0 %) and stage-5 (83.1 %), respectively,
and decreased thereafter. Total CT scores increased from stage-1 to stage-2 (2.8 ± 3.1,
vs. 6.5 ± 4.6, respectively, P < 0.01), and thereafter remained high. The lower lobes
were more inclined to be involved with higher CT scores except for stage-1. At stage-6
98.1 % of CT scans still showed abnormalities (CT score 7.5 ± 4.1).
Thin-section CT could provide semi-quantitative analysis of pulmonary damage severity.
This disease changed rapidly at the early stage, then tended to be stable and lasted
for a long time.