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Gray matter abnormalities in Internet addiction: A voxel-based morphometry study

  • Author Footnotes
    1 These authors contributed equally to this work.
    Yan Zhou
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Radiology, RenJi Hospital, Jiao Tong University Medical School, Shanghai 200127, PR China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Fu-chun Lin
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Ya-song Du
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Child & Adolescent Psychiatry Shanghai Mental Health Center, Shanghai Jiao Tong University, Shanghai 200030, PR China
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  • Ling-di Qin
    Affiliations
    Department of Radiology, RenJi Hospital, Jiao Tong University Medical School, Shanghai 200127, PR China
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  • Zhi-min Zhao
    Affiliations
    Department of Child & Adolescent Psychiatry Shanghai Mental Health Center, Shanghai Jiao Tong University, Shanghai 200030, PR China
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  • Jian-rong Xu
    Correspondence
    Corresponding author at: Department of Radiology, RenJi Hospital, Jiao Tong University Medical School, No. 1630 Dongfang Road, Shanghai 200127, PR China. Tel.: +86 21 5875 2345x3059.
    Affiliations
    Department of Radiology, RenJi Hospital, Jiao Tong University Medical School, Shanghai 200127, PR China
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  • Hao Lei
    Correspondence
    Corresponding author at: State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, West No. 30 Xiao Hong Shan, Wuhan 430071, PR China. Tel.: +86 27 8719 8542; fax: +86 27 8719 9291.
    Affiliations
    State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China
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  • Author Footnotes
    1 These authors contributed equally to this work.

      Abstract

      Background

      This study aims to investigate brain gray matter density (GMD) changes in adolescents with Internet addiction (IA) using voxel-based morphometry (VBM) analysis on high-resolution T1-weighted structural magnetic resonance images.

      Methods

      Eighteen IA adolescents and 15 age- and gender-matched healthy controls took part in this study. High-resolution T1-weighted magnetic resonance imaging scans were performed on the two groups. VBM analysis was used to compare the GMD between the two groups.

      Results

      Compared with healthy controls, IA adolescents had lower GMD in the left anterior cingulate cortex, left posterior cingulate cortex, left insula, and left lingual gyrus.

      Conclusions

      Our findings suggested that brain structural changes were present in IA adolescents, and this finding may provide a new insight into the pathogenesis of IA.

      Keywords

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