1H MR spectroscopy of inflammation, infection and ischemia of the brain

  • Irina Mader
    Corresponding author at: Section of Neuroradiology, Neurocenter of the Freiburg University Hospital, Breisacher Street 64, 79106 Freiburg, Germany. Tel.: +49 761 270 5192; fax: +49 761 270 5195.
    Section of Neuroradiology, Neurocenter of the Freiburg University Hospital, Breisacher Street 64, D-79106 Freiburg, Germany

    Freiburg Brain Imaging Center, Department of Neurology of the Freiburg University Hospital, Breisacher Street 64, D-79106 Freiburg, Germany
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  • Sebastian Rauer
    Department of Neurology of the Freiburg University Hospital, Breisacher Street 64, D-79106 Freiburg, Germany
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  • Peter Gall
    Department of Radiology, Medical Physics, University Hospital Freiburg, Hugstetter Street 49, 79095 Freiburg, Germany
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  • Uwe Klose
    Section of Experimental MR of the CNS, Department of Neuroradiology, Radiological University Hospital, Hoppe-Seyler-Street 3, 72076 Tübingen, Germany
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      Different pathologic patterns in multiple sclerosis (MS) are reflected by alterations of metabolites in 1H MR spectroscopy of the brain. Elevated choline (Cho), lactate (Lac), lipids and macromolecules are reliable markers for acute demyelination regardless of the clinical entity (also in acute disseminated encephalomyelitis). N-acetyl-aspartate (NAA) is a suitable marker for neuronal integrity. It is reduced in acute MS lesions and in normal appearing white matter, even distant to acute and chronic-lesions. Recovery from reduced NAA levels to subnormal values during remyelination, and varying time courses of NAA in normal appearing white matter during relapsing remitting disease indicate the value of this spectroscopic marker for monitoring activity and recovery. Inositol (Ins) is increased in chronic MS lesions being a marker for astrocytic gliosis. In viral disease, Cho and Ins are always increased, whereas a reduction of NAA mostly reflects an advanced or a detoriated clinical state. In bacterial brain abscesses, numerous amino acids, lipids and Lac can be elevated. In ischemia, especially the Lac/NAA in comparison with perfusion and diffusion weighted imaging seems to be a new measure for areas of metabolic need, and may help to better characterise the penumbra of the stroke and the final infarct size.


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