Screening mammography for breast cancer detection has led to the development of various imaging modalities. Some utilize ionizing and others non-ionizing radiation. The well-known advantages of X-rays have resulted in various imaging modalities with the intention of enhancing safety and efficacy. Digital mammography spawned the development of several derived technologies, including digital breast tomosynthesis (DBT) and contrast-enhanced digital mammography (CEDM) . Combining DBT with CEDM has been shown to limit the effect of surrounding soft tissue and achieving higher contrast between malignancy and surrounding tissue .