European Journal of Radiology
Volume 81, Issue 2 , Pages 214-217, February 2012

MRI morphological classification of ductal carcinoma in situ (DCIS) correlating with different biological behavior

  • Haiquan Liu

      Affiliations

    • Department of Radiology, Cancer center, Fudan University, Shanghai 200032, China
    • Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    • Corresponding Author InformationCorresponding author at: Department of Radiology, Cancer Hospital, Fudan University, 270 Dong-An Road, Shanghai 200032, China. Fax: +86 21 64433384.
    • ,
  • Weijun Peng

      Affiliations

    • Department of Radiology, Cancer center, Fudan University, Shanghai 200032, China
    • Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    • Corresponding Author InformationCorresponding author at: Department of Radiology, Cancer Hospital, Fudan University, 270 Dong-An Road, Shanghai 200032, China. Fax: +86 21 64433384.

Received 20 October 2010; accepted 22 December 2010.

Abstract 

Objective

To investigate morphological appearance of ductal carcinoma in situ of breast on MRI and to correlate the appearances with some factors.

Methods and materials

MRI feature of 41 DCISs were analyzed retrospectively according to ACR BI-RADS, twenty-three of the 41 were pure DCIS and 18 were DCIS with microinvasion (DCIS-MI). The shape was categorized as mass lesion and non-mass-like lesion. The shape was correlated with histological grade, ER status and expression of e-erbB2 as well as pure DCIS or DCIS-MI.

Results

Percentage of high grade in non-mass-like lesion was higher than that in mass type group, Average size of tumor in group of high grade, negative ER status and positive c-erbB2 expression were larger than that in non-high grade, positive ER status and negative c-erbB2 expression. Comparing pure DCIS and DCIS-MI, high grade in DCIS-MI was significantly higher than that in pure DCIS, Average size of DCIS-MI was larger than that in pure DCIS. Percentage of non-mass-like lesion was higher in DCIS-IM than that in pure DCIS, the difference was marginally significant.

Conclusion

DCIS can be classified as mass type and non-mass-like type morphologically on MRI. The two types reflect different biological behavior.

Keywords: Ductal carcinoma in situ (DCIS), Ductal carcinoma in situ with microinvasion, Magnetic resonance imaging, Hormone status

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PII: S0720-048X(11)00033-7

doi:10.1016/j.ejrad.2010.12.084

European Journal of Radiology
Volume 81, Issue 2 , Pages 214-217, February 2012

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