Whole-brain voxel-based morphometry of white matter in mild cognitive impairment

Wang, Zhiqun; Guo, Xiaojuan; Qi, Zhigang; Yao, Li; Li, Kuncheng

doi:10.1016/j.ejrad.2009.04.041

« Previous Next »European Journal of Radiology
Volume 75, Issue 2 , Pages 129-133, August 2010

Whole-brain voxel-based morphometry of white matter in mild cognitive impairment

Zhiqun Wang
- Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China
Xiaojuan Guo
- College of Information Science and Technology, Beijing Normal University, 100875, Beijing, China
- National Key Laboratory for Cognitive Neuroscience and Learning, Beijing Normal University, 100875, Beijing, China
Zhigang Qi
- Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China
Li Yao
- College of Information Science and Technology, Beijing Normal University, 100875, Beijing, China
- National Key Laboratory for Cognitive Neuroscience and Learning, Beijing Normal University, 100875, Beijing, China
Kuncheng Li
- Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China
- Corresponding author. Tel.: +86 10 83198376; fax: +86 10 83198376.

Received 10 February 2009; accepted 15 April 2009.

Abstract

Purpose

The purpose of this study was to analyze whole-brain white matter changes in mild cognitive impairment (MCI).

Materials and methods

We studied 14 patients with MCI and 14 age- and sex-matched healthy control subjects using voxel-based morphometry (VBM) on T1-weighted 3D datasets. The data were collected on a 3T MR system and analyzed by SPM2 to generate white matter volume maps.

Results

Voxel-based morphometry revealed diffusively reduced white matter in MCI prominently including the bilateral temporal gyrus, the right anterior cingulate, the bilateral superior and medial frontal gyrus and right parietal angular gyrus. White matter reduction was more prominent in anterior regions than that in posterior regions.

Conclusion

Whole-brain white matter reduction in MCI patients detected with VBM has special distribution which is in line with the white matter pathology of MCI.

Keywords: Voxel-based morphometry, Magnetic resonance imaging, Mild cognitive impairment