European Journal of Radiology
Volume 75, Issue 2 , Pages 134-138 , August 2010

Regional diffusion changes of cerebral grey matter during normal aging—A fluid-inversion prepared diffusion imaging study

  • Jian-ming Ni

      Affiliations

    • Radiology Department, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Urumqi Middle Road, Shanghai 200040, China
    • Nuclear Medicine Department, Renji Hospital, Medical School of Jiaotong University, Dongfang Road 1630, Shanghai, 200127, China
    • Medical Imaging Department, Wuxi Second Hospital Affiliated Nanjing Medical University, 68 Zhong Shan Road, Wuxi, Jiangsu Province, 200124, China
    • ,
  • Shuang Chen

      Affiliations

    • Radiology Department, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Urumqi Middle Road, Shanghai 200040, China
    • ,
  • Jian-jun Liu

      Affiliations

    • Nuclear Medicine Department, Renji Hospital, Medical School of Jiaotong University, Dongfang Road 1630, Shanghai, 200127, China
    • ,
  • Gang Huang

      Affiliations

    • Nuclear Medicine Department, Renji Hospital, Medical School of Jiaotong University, Dongfang Road 1630, Shanghai, 200127, China
    • Corresponding Author InformationCorresponding author at: Dongfang Road 1630, Shanghai 200127, China. Tel.: +86 21 50892400; fax: +86 21 50892400.
    • ,
  • Tian-zhen Shen

      Affiliations

    • Radiology Department, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Urumqi Middle Road, Shanghai 200040, China
    • ,
  • Xing-rong Chen

      Affiliations

    • Radiology Department, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Urumqi Middle Road, Shanghai 200040, China
    • Nuclear Medicine Department, Renji Hospital, Medical School of Jiaotong University, Dongfang Road 1630, Shanghai, 200127, China

Received 5 October 2008 ,Revised 13 April 2009 ,Accepted 14 April 2009.

Reference 

  1. Sykova E, Mazel T, Simonova Z. Diffusion constraints and neuron-glia interaction during aging. Exp Gerontol. 1998;33:837–851
  2. Sullivan EV, Adalsteinsson E, Pfefferbaum A. Selective age related degradation of anterior callosal fiber bundles quantified in vivo with fiber tracking. Cerebral Cortex. 2006;16:1030–1039
  3. Sullivan EV, Pfefferbaum A. Diffusion tensor imaging and aging. Neurosci Biobehav Rev. 2006;30:749–761
  4. Kantarci K, Petersen RC, Boeve BF, et al. DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment. Neurology. 2005;64:902–904
  5. Bykowski JL, Latour LL, Warach S. More accurate identification of reversible ischemic injury in human stroke by cerebrospinal fluid suppressed diffusion-weighted imaging. Stroke. 2004;35:1100–1106
  6. Engelter ST, Provenzale JM, Petrella JR, et al. The effect of aging on the apparent diffusion coefficient of normal appearing white matter. AJR Am J Roentgenol. 2000;175:425–430
  7. Nusbaum AO, Tang CY, Buchsbaum MS, et al. Regional and global changes in cerebral diffusion with normal aging. AJNR Am J Neuroradiol. 2001;22:136–142
  8. Naganawa S, Sato K, Katagiri T, et al. Regional ADC values of the normal brain: differences due to age, gender, and laterality. Eur Radiol. 2003;13:6–11
  9. Chun T, Filippi CG, Zimmerman RD, et al. Diffusion changes in the aging human brain. AJNR Am J Neuroradiol. 2000;21:1078–1083
  10. Helenius J, Soinne L, Perkiö J, et al. Diffusion-weighted MR imaging in normal human brains in various age groups. AJNR Am J Neuroradiol. 2002;23:194–199
  11. Wilson RS, Schneider JA, Bienias JL, et al. Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons. Neurology. 2003;61:1102–1107
  12. Lampe IK, Hulshoff Pol HE, Janssen J, et al. Association of depression duration with reduction of global cerebral gray matter volume in female patients with recurrent major depressive disorder. Am J Psychiatry. 2003;160:2052–2054
  13. Zetzsche T, Preuss U, Frodl T, et al. In-vivo topography of structural alterations of the anterior cingulate in patients with schizophrenia: new findings and comparison with the literature. Schizophr Res. 2007;96:34–45
  14. Latour LL, Warach S. Cerebral spinal fluid contamination of the measurement of the apparent diffusion coefficient of water in acute stroke. Magn Reson Med. 2002;48:478–486
  15. Steens SC, Admiraal-Behloul F, Schaap JA, et al. Reproducibility of brain ADC histograms. Eur Radiol. 2004;14:425–430
  16. Ma X, Kadah YM, LaConte SM, et al. Enhancing measured diffusion anisotropy in gray matter by eliminating CSF contamination with FLAIR. Magn Reson Med. 2004;51:423–427
  17. Benedetti B, Charil A, Rovaris M, et al. Influence of aging on brain gray and white matter changes assessed by conventional, MT, and DT MRI. Neurology. 2006;66:535–539
  18. Gideon P, Thomsen C, Henriksen O. Increased self-diffusion of brain water in normal aging. J Magn Reson Imaging. 1994;4:185–188
  19. Pfefferbaum A, Adalsteinsson E, Spielman D, et al. In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging. Magn Reson Med. 1999;41:276–284
  20. Huisman TA, Loenneker T, Barta G, et al. Quantitative diffusion tensor MR imaging of the brain: field strength related variance of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) scalars. Eur Radiol. 2006;16:1651–1658
  21. Sasaki M, Yamada K, Watanabe Y, et al. Variability in absolute apparent Diffusion coefficient values across different platforms may be substantial: a multivendor, multi-institutional comparison study. Radiology. 2008;249:624–630
  22. Dickstein DL. Changes in the structural complexity of the aged brain. Aging Cell. 2007;6:275–284
  23. Jacobs B, Driscoll L, Schall M. Life-span dendritic and spine changes in areas 10 and 18 of human cortex: a quantitative Golgi study. J Comp Neurol. 1997;386:661–680
  24. Huttenlocher PR. Synaptic density in human frontal cortex-developmental changes and effects of aging. Brain Res. 1979;163:195–205
  25. Hatanpaa K, Isaacs KR, Shirao T, et al. Loss of proteins regulating synaptic plasticity in normal aging of the huaman brain and in Alzheimer desease. J Neuropathol Exp Neurol. 1999;58:637–643
  26. Pfefferbaum A, Sullivan EV, Carmelli D. Genetic regulation of regional microstructure of the corpus callosum in late life. Neuroreport. 2001;12:1677–1681
  27. Sowell ER, Peterson BS, Thompson PM, et al. Mapping cortical change across the human life span. Nat Neurosci. 2003;6:309–315
  28. Tapp PD, Siwak CT, Gao FQ, et al. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci. 2004;24:8205–8213
  29. Grieve SM, Clark CR, Williams LM, et al. Preservation of limbic and paralimbic structures in aging. Hum Brain Mapp. 2005;25:391–401
  30. Kalpouzos G, Chételat G, Baron JC, et al. Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging. Neurobiol Aging. 2009;30:112–124
  31. Rodrigo S, Naggara O, Oppenheim C, et al. Human subinsular asymmetry studied by diffusion tensor imaging and fiber tracking. AJNR Am J Neuroradiol. 2007;28:1526–1531
  32. Toga AW, Thompson PM. Mapping brain asymmetry. Nat Rev Neurosci. 2003;4:37–48
  33. Luders E, Narr KL, Thompson PM, et al. Hemispheric asymmetries in cortical thickness. Cerebral Cortex. 2006;16:1232–1238
  34. Liu T, Young G, Huang L, et al. 76-Space analysis of grey matter diffusivity: Methods and applications. NeuroImage. 2006;31:51–65
  35. Simon JE, Czechowsky DK, Hill MD, et al. Fluid-attenuated inversion recovery preparation: not an improvement over conventional diffusion-weighted imaging at 3T in acute ischemic stroke. AJNR Am J Neuroradiol. 2004;25:1653–1658

PII: S0720-048X(09)00226-5

doi: 10.1016/j.ejrad.2009.04.028

European Journal of Radiology
Volume 75, Issue 2 , Pages 134-138 , August 2010

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