Effect of cardiac function on aortic peak time and peak enhancement during coronary CT angiography

Sakai, Shuji; Yabuuchi, Hidetake; Chishaki, Akiko; Okafuji, Takashi; Matsuo, Yoshio; Kamitani, Takeshi; Setoguchi, Taro; Honda, Hiroshi

doi:10.1016/j.ejrad.2009.04.022

« Previous Next »European Journal of Radiology
Volume 75, Issue 2 , Pages 173-177, August 2010

Effect of cardiac function on aortic peak time and peak enhancement during coronary CT angiography

Shuji Sakai
- Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Tel.: +81 92 642 5695; fax: +81 92 642 5695.
- Corresponding author at: Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Tel.: +81 92 642 6727; fax: +81 92 642 6727.
Hidetake Yabuuchi
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Tel.: +81 92 642 5695; fax: +81 92 642 5695.
Akiko Chishaki
- Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Tel.: +81 92 642 6727; fax: +81 92 642 6727.
- Tel.: +81 92 642 5360; fax: +81 92 642 5375.
Takashi Okafuji
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Tel.: +81 92 642 5695; fax: +81 92 642 5695.
Yoshio Matsuo
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Tel.: +81 92 642 5695; fax: +81 92 642 5695.
Takeshi Kamitani
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Tel.: +81 92 642 5695; fax: +81 92 642 5695.
Taro Setoguchi
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Tel.: +81 92 642 5695; fax: +81 92 642 5695.
Hiroshi Honda
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
- Tel.: +81 92 642 5695; fax: +81 92 642 5695.

Received 22 January 2009; received in revised form 7 April 2009; accepted 7 April 2009.

Abstract

Purpose

To examine the manner in which cardiac function affects the magnitude and timing of aortic contrast enhancement during coronary CT angiography (CTA).

Materials and methods

Twenty-nine patients (21 men, 8 women; mean age, 64.4±13.4 years; mean weight, 59.4±10.3kg) underwent measurement of cardiac output within 2 weeks of coronary CTA. The cardiac output of each patient was measured by the thermodilution technique and the cardiac index was calculated from the body surface area. During coronary CTA, attenuation of the descending aorta was measured at the workstation every 3s. The aortic peak time (APT) and aortic peak enhancement (APE) of each patient were calculated. Pearson's correlation coefficient analysis was used to investigate the relationships between the cardiac output or cardiac index and APT or APE. Furthermore, the relationship between patient factors or parameters on test bolus injection and APT or APE was also evaluated.

Results

The range of cardiac output, cardiac index, APT, and APE was 1.55–10.46L/min (mean: 4.77±2.13), 1.11–5.30L/(min-m²) (mean: 3.28±1.08), 25–51s (mean: 38.3±7.5), and 273.1–598.1HU (mean: 390.4±72.1), respectively. With an increase in the cardiac index, both APT (r=−0.698, p<0.0001) and APE (r=−0.573, p=0.0009) decreased. There were significant correlations between the patient body weight and APT and APE with the test bolus injection, and with APT and APE during coronary CTA.