European Journal of Radiology
Volume 75, Issue 1 , Pages 72-81 , July 2010

MRI evaluation of a new scaffold-based allogenic chondrocyte implantation for cartilage repair

  • A.A.M. Dhollander

      Affiliations

    • Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, De Pintelaan 185, 1P5, B9000 Gent, Belgium
    • Both authors have contributed equally to this article and share first authorship.
    • Corresponding Author InformationCorresponding author. Tel.: +32 0498 50 11 65.
    • ,
  • W.C.J. Huysse

      Affiliations

    • Department of Radiology, Ghent University Hospital, De Pintelaan 185, -1K12 IB, B9000 Gent, Belgium
    • Both authors have contributed equally to this article and share first authorship.
    • Tel.: +32 09 332 6685; fax: +32 09 332 6145.
    • ,
  • P.C.M. Verdonk

      Affiliations

    • Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, De Pintelaan 185, 1P5, B9000 Gent, Belgium
    • Tel.: +32 09 332 4708.
    • ,
  • K.L. Verstraete

      Affiliations

    • Department of Radiology, Ghent University Hospital, De Pintelaan 185, -1K12 IB, B9000 Gent, Belgium
    • Tel.: +32 09 332 2912.
    • ,
  • R. Verdonk

      Affiliations

    • Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, De Pintelaan 185, 1P5, B9000 Gent, Belgium
    • Tel.: +32 09 332 2227.
    • ,
  • G. Verbruggen

      Affiliations

    • Laboratory of Connective Tissue Biology, Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    • Tel.: +32 09 332 2250.
    • ,
  • K.F. Almqvist

      Affiliations

    • Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, De Pintelaan 185, 1P5, B9000 Gent, Belgium
    • Tel.: +32 09 332 22 24; fax: +32 09 332 49 75.

Received 29 September 2008 ,Revised 2 February 2009 ,Accepted 4 March 2009.

References 

  1. Imhof H, Nöbauer-Huhmann IM, Krestan C, et al. MRI of the cartilage. Eur Radiol. 2002;12:2781–2793
  2. Trattnig S, Huber M, Breitenseher MJ, et al. Imaging articular cartilage defects with 3D fat-suppressed echo planar imaging: comparison with conventional 3D fat-suppressed gradient echo sequence and correlation with histology. J Comput Assist Tomogr. 1998;22:8–14
  3. Potter HG, Linklater JM, Allen AA, Hannafin JA, Haas SB. Magnetic resonance imaging of articular cartilage in the knee. An evaluation with use of fast-spin-echo imaging. J Bone Joint Surg Am. 1998;80:1276–1284
  4. Recht M, White LM, Winalski CS, Miniaci A, Minas T, Parker RD. MR imaging of cartilage repair procedures. Skeletal Radiol. 2003;32:185–200
  5. Recht MP, Piraino DW, Paletta GA, Schils JP, Belhobek GH. Accuracy of fat-suppressed three-dimensional spoiled gradient-echo FLASH MR imaging in the detection of patellofemoral articular cartilage abnormalities. Radiology. 1996;198:209–212
  6. Disler DG, McCauley TR, Kelman CG, et al. Fat-suppressed three dimensional spoiled gradient-echo MR imaging of hyaline cartilage defects in the knee: comparison with standard MR imaging and arthroscopy. Am J Roentgenol. 1996;167:127–132
  7. Trattnig S, Mlynarik V, Huber M, Ba-Ssalamah A, Puig S, Imhof H. Magnetic resonance imaging of articular cartilage and evaluation of cartilage disease. Invest Radiol. 2000;35:595–601
  8. Marlovits S, Striessnig G, Resinger CT, et al. Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging. Eur J Radiol. 2004;52:310–319
  9. Marlovits S, Singer P, Zeller P, Mandl I, Haller J, Trattnig S. Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. Eur J Radiol. 2006;57:16–23
  10. Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG. Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy. 2003;19:477–484
  11. Hangody L, Füles P. Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weight-bearing joints: ten years of experimental and clinical experience. J Bone Joint Surg Am. 2003;85:25–32
  12. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994;331:889–895
  13. Peterson L, Brittberg M, Kiviranta I, Åkerlund EL, Lindahl A. Autologous chondrocyte transplantation. Biomechanics and long-term durability. Am J Sports Med. 2002;30:2–12
  14. Sgaglione N, Miniaci A, Gillogly S, Carter TR. Update on advanced surgical techniques in the treatment of traumatic focal articular cartilage lesions in the knee. Arthroscopy. 2002;18:9–32
  15. Benya PD, Schaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell. 1982;30:215–224
  16. Almqvist KF. Human differentiated articular cartilage cells in biodegradable matrices. Preparative studies for their use in the repair of cartilage defects. A thesis submitted for fulfilment of the requirements for the degree: ‘Doctor in the Medical Sciences’. Ghent, Belgium; 2001.
  17. Almqvist KF, Wang L, Wang J, et al. Culture of chondrocytes in alginate surrounded by fibrin gel: characteristics of the cells over a period of eight weeks. Ann Rheum Dis. 2001;60:781–790
  18. Hjelle K, Solheim E, Strand T, Muri R, Brittber GM. Articular cartilage defects in 1,000 knee arthroscopies. Arthroscopy. 2002;18:730–734
  19. Verdonk PCM, Demurie A, Almqvist KF, Veys EM, Verbruggen G, Verdonk R. Transplantation of viable meniscal allograft. Survivorship analysis and clinical outcome of one hundred cases. J Bone Joint Surg Am. 2005;87:715–724
  20. Green WT. Behaviour of articular chondrocytes in cell culture. Clin Orthop. 1971;75:248–260
  21. Kuettner KE, Pauli BU, Gall G, McMemoli VA, Schenk RA. Synthesis of cartilage matrix by mammalian chondrocytes in vivo. I. Isolation, culture characteristics and morphology. J Cell Biol. 1982;93:743–750
  22. Cornelissen M, Verbruggen G, Malfait AM, Veys EM, Broddelez C, De Ridder L. The study of representative populations of native aggrecan aggregates synthesized by human chondrocytes in vitro. J Tiss Cult Meth. 1993;15:139–146
  23. Guo J, Jourdian GW, MacCallum DK. Culture and growth characteristics of chondrocytes encapsulated in alginate beads. Connect Tissue Res. 1989;9:277–297
  24. Minas T. Autologous chondrocyten implantation for focal chondral defects of the knee. Clin Orthop Relat Res. 2001;391:349–361
  25. Marlovits S, Zeller P, Singer P, Resinger C, Vécsei V. Cartilage repair: generations of autologous chondrocyte transplantation. Eur J Radiol. 2006;57:24–31
  26. Bijur PE, Silver W, Gallagher EJ. Reliability of the visual analog scale for measurement of acute pain. Acad Emerg Med. 2001;8:1153–1157
  27. Gallaher EJ, Bijur PE, Laimer C, Silver W. Reliability and validity of a visual analog scale for acute abdominal pain in the ED. Am J Emerg Med. 2002;20:287–290
  28. Atala A, Kim W, Paige KT, Vacanti CA, Retik AB. Endoscopic treatment of vesicoureteral reflux with a chondrocyte-alginate suspension. J Urol. 1994;152:641–643
  29. Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage. 2002;10:432–463
  30. Knutsen G, Engebretsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am. 2004;86:455–464
  31. Tins BJ, McCall IW, Takashi T, et al. Autologous chondrocyte implantation in knee joint: MR imaging and histologic features at 1-year follow-up. Radiology. 2005;234:501–508
  32. Radin EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res. 1986;213:34–40
  33. Bobic V, Noble J. Articular cartilage—to repair or not to repair. J Bone Joint Surg Br. 2000;82:165–166
  34. Gold GE, McCauley TR, Gray ML, Disler DG. What's new in cartilage?. Radiographics. 2003;23:1227–1242
  35. McCauley TR, Disler DG. Magnetic resonance imaging of articular cartilage of the knee. J Am Acad Orthop Surg. 2001;9:2–8
  36. Henderson IJ, Tuy B, Connell D, Oakes B, Hettwer WH. Prospective clinical study of autologous chondrocyte implantation and correlation with MRI at three and 12 months. J Bone Joint Surg Br. 2003;85:1060–1066
  37. Görtz S, Bugbee WD. Allografts in articular cartilage repair. J Bone Joint Surg. 2006;88:1374–1384
  38. Minas T, Peterson L. Advanced techniques in autologous chondrocyte transplantation. Clin Sports Med. 1999;18:13–44
  39. Marlovits S, Khanakah G, Striessnig G, Vévsei V, Stanek G. Emergence of lyme arthritis after autologous chondrocyte transplantation. Arthritis Rheum. 2004;50:259–264
  40. Marcacci M, Kon E, Zaffagnini S, et al. Arthroscopic second generation autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc. 2007;15:610–619
  41. Ossendorf C, Kaps C, Kreuz PC, Burmester GR, Sittinger M, Erggelet C. Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res. Therapy. 2007;9:R41
  42. Nehrer S, Domayer S, Dorotka R, Schatz K, Bindreiter U, Kotz R. Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol. 2006;57:3–8
  43. Manfredini M, Zerbinati F, Gildone A, Faccini R. Autologous chondrocyte implantation: a comparison between an open periosteal-covered and an arthroscopic matrix-guided technique. Acta Orthop Belg. 2007;73:207–218
  44. Gobbi A, Kon E, Berruto M, Francisco R, Filardo G, Marcacci M. Patellofemoral full-thickness chondral defects treated with Hyalograft-C: a clinical, arthroscopic, and histologic review. Am J Sports Med. 2006;34:1763–1773
  45. Behrens P, Bitter T, Kurz B, Russlies M. Matrix-associated autologous chondrocyte transplantation/implantation (MATC/MACI)-5-year follow-up. Knee. 2006;13:194–202
  46. Jakobsen RB, Engebretsen L, Slauterbeck JR. An analysis of the quality of cartilage repair studies. J Bone Joint Surg. 2005;87:2232–2239
  47. Treppo S, Koepp H, Quan EC, Cole AA, Kuettner KE, Grodzinsky AJ. Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs. J Orthop Res. 2000;18:739–748
  48. Verbruggen G, Cornelissen M, Almqvist KF, et al. Influence of aging on the synthesis and morphology of the aggrecans synthesized by differentiated human articular chondrocytes. Osteoarthritis Cartilage. 2000;8:170–179
  49. Saris DBF, Vanlauwe J, Victor J, et al. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med. 2008;36:235–246
  50. Genes NG, Rowley JA, Mooney DJ, Bonassar LJ. Effect of substrate mechanics on chondrocyte adhesion to modified alginate surfaces. Arch Biochem Biophys. 2004;422:161–167
  51. Rowley JA, Madlambayan G, Mooney DJ. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials. 1999;20:45–53

PII: S0720-048X(09)00124-7

doi: 10.1016/j.ejrad.2009.03.056

European Journal of Radiology
Volume 75, Issue 1 , Pages 72-81 , July 2010

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