European Journal of Radiology
Volume 73, Issue 2 , Pages 280-287 , February 2010

Imaging anti-angiogenic treatment response with DCE-VCT, DCE-MRI and DWI in an animal model of breast cancer bone metastasis

  • Tobias Bäuerle

      Affiliations

    • Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 6221 422553; fax: +49 6221 422572.
    • ,
  • Sönke Bartling

      Affiliations

    • Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    • Tel.: +49 6221 422686; fax: +49 6221 422572.
    • ,
  • Martin Berger

      Affiliations

    • Unit of Chemotherapy and Toxicology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    • Tel.: +49 6221 423310; fax: +49 6221 423313.
    • ,
  • Annette Schmitt-Gräff

      Affiliations

    • Institute of Pathology, University of Freiburg, Postfach 214, 79002 Freiburg, Germany
    • Tel.: +49 761 2036776; fax: +49 761 2036790.
    • ,
  • Heidegard Hilbig

      Affiliations

    • Institute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, Germany
    • Tel.: +49 341 9722053.
    • ,
  • Hans-Ulrich Kauczor

      Affiliations

    • Department of Diagnostic and Interventional Radiology, Radiologische Klinik, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    • Tel.: +49 6221 566410.
    • ,
  • Stefan Delorme

      Affiliations

    • Department of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    • Tel.: +49 6221 2563; fax: +49 6221 422567.
    • ,
  • Fabian Kiessling

      Affiliations

    • Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    • Department of Experimental Molecular Imaging, RWTH Aachen, Pauwelsstraße 20, 52074 Aachen, Germany
    • Tel.: +49 241 8080117; fax: +49 241 8082442.

Received 1 September 2008 ,Revised 22 October 2008 ,Accepted 23 October 2008.

References 

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  2. Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007;357:2666–2676
  3. Bäuerle T, Hilbig H, Bartling S, et al. Bevacizumab inhibits breast cancer induced osteolysis, surrounding soft tissue metastasis, and angiogenesis in rats as visualized by VCT and MRI. Neoplasia. 2008;10:511–520
  4. Hayward JL, Carbone PP, Heusen JC, Kumaoka S, Segaloff A, Rubens RD. Assessment of response to therapy in advanced breast cancer. Br J Cancer. 1997;35:292–298
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  10. Moehler TM, Hawighorst H, Neben K, et al. Bone marrow microcirculation analysis in multiple myeloma by contrast-enhanced dynamic magnetic resonance imaging. Int J Cancer. 2001;93:862–868
  11. Hillengass J, Wasser K, Delorme S, et al. Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma. Clin Cancer Res. 2007;13:475–481
  12. Bäuerle T, Adwan H, Kiessling F, Hilbig H, Armbruster FP, Berger MR. Characterization of a rat model with site-specific bone metastasis induced by MDA-MB-231 breast cancer cells and its application to the effects of an antibody against bone sialoprotein. Int J Cancer. 2005;115:177–186
  13. Kiessling F, Heilmann M, Vosseler S, et al. Dynamic T1-weighted monitoring of vascularization in human carcinoma heterotransplants by magnetic resonance imaging. Int J Cancer. 2003;104:113–120
  14. Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer. 2002;2:584–593
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  17. Lee KC, Sud S, Meyer CR, et al. An imaging biomarker of early treatment response in prostate cancer that has metastasized to the bone. Cancer Res. 2007;67:3524–3528
  18. Kiessling F, Farhan N, Lichy MP, et al. Dynamic contrast-enhanced magnetic resonance imaging rapidly indicates vessel regression in human squamous cell carcinomas grown in nude mice caused by VEGF receptor 2 blockade with DC101. Neoplasia. 2004;6:213–223
  19. Zwick S, Woenne EC, Strecker R, et al. Combined use of DCE-MRI and VSI to monitor an antiangiogenic therapy against VEGF in tumor xenografts. In: Abstract of the 16th Annual Scientific Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM). 2008;
  20. Lee KC, Bradley DA, Hussain M, et al. A feasibility study evaluating the functional diffusion map as a predictive imaging biomarker for detection of treatment response in a patient with metastatic prostate cancer to the bone. Neoplasia. 2007;9:1003–1011

PII: S0720-048X(08)00578-0

doi: 10.1016/j.ejrad.2008.10.020

European Journal of Radiology
Volume 73, Issue 2 , Pages 280-287 , February 2010

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