European Journal of Radiology
Volume 64, Issue 3 , Pages 367-374 , December 2007

MR microscopy of the lung in small rodents

  • Masaya Takahashi

      Affiliations

    • Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, United States
    • Corresponding Author InformationCorresponding author at: Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, United States. Tel.: +1 617 667 1098; fax: +1 617 667 7021.
  • ,
  • Shigeto Kubo

      Affiliations

    • Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, United States
  • ,
  • Shigeru Kiryu

      Affiliations

    • Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, United States
  • ,
  • James Gee

      Affiliations

    • Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, United States
  • ,
  • Hiroto Hatabu

      Affiliations

    • Department of Radiology and Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States

Received 30 July 2007 ,Revised 31 July 2007 ,Accepted 1 August 2007.

References 

  1. Hansell DM. High-resolution computed tomography in the evaluation of fibrosing alveolitis. Clin Chest Med. 1999;20(4):739–760
  2. Kazerooni EA. Radiologic evaluation of emphysema for lung volume reduction surgery. Clin Chest Med. 1999;20(4):845–861
  3. Muller NL, Staples CA, Miller RR, Abboud RT. “Density mask”. An objective method to quantitate emphysema using computed tomography. Chest. 1988;94(4):782–787
  4. Alsop DC, Hatabu H, Bonnet M, Listerud J, Gefter W. Multi-slice, breathhold imaging of the lung with submillisecond echo times. Magn Reson Med. 1995;33(5):678–682
  5. Hatabu H, Chen Q, Stock KW, Gefter WB, Itoh H. Fast magnetic resonance imaging of the lung. Eur J Radiol. 1999;29(2):114–132
  6. Hatabu H, Gaa J, Kim D, Li W, Prasad PV, Edelman RR. Pulmonary perfusion: qualitative assessment with dynamic contrast-enhanced MRI using ultra-short TE and inversion recovery turbo FLASH. Magn Reson Med. 1996;36(4):503–508
  7. Hatabu H, Gaa J, Kim D, Li W, Prasad PV, Edelman RR. Pulmonary perfusion and angiography: evaluation with breath-hold enhanced three-dimensional fast imaging steady-state precession MR imaging with short TR and TE. AJR Am J Roentgenol. 1996;167(3):653–655
  8. Amundsen T, Kvaerness J, Jones RA, et al. Pulmonary embolism: detection with MR perfusion imaging of lung—a feasibility study. Radiology. 1997;203(1):181–185
  9. Berthezene Y, Croisille P, Bertocchi M, Houzard C, Bendib K, Revel D. Lung perfusion demonstrated by contrast-enhanced dynamic magnetic resonance imaging. Application to unilateral lung transplantation. Invest Radiol. 1997;32(6):351–356
  10. Ohno Y, Chen Q, Hatabu H. Oxygen-enhanced magnetic resonance ventilation imaging of lung. Eur J Radiol. 2001;37(3):164–171
  11. Albert MS, Cates GD, Driehuys B, et al. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature. 1994;370(6486):199–201
  12. Ebert M, Grossmann T, Heil W, et al. Nuclear magnetic resonance imaging with hyperpolarised helium-3. Lancet. 1996;347(9011):1297–1299
  13. Salerno M, Altes TA, Brookeman JR, de Lange EE, Mugler JP. Dynamic spiral MRI of pulmonary gas flow using hyperpolarized (3)He: preliminary studies in healthy and diseased lungs. Magn Reson Med. 2001;46(4):667–677
  14. Travis WD, Travis LB, Devesa SS. Lung cancer. Cancer. 1995;75(Suppl 1):191–202
  15. Gardi C, Martorana PA, Calzoni P, et al. Lung collagen synthesis and deposition in tight-skin mice with genetic emphysema. Exp Mol Pathol. 1992;56(2):163–172
  16. Gayraud B, Keene DR, Sakai LY, Ramirez F. New insights into the assembly of extracellular microfibrils from the analysis of the fibrillin 1 mutation in the tight skin mouse. J Cell Biol. 2000;150(3):667–680
  17. Feldkamp LA, Goldstein SA, Parfitt AM, Jesion G, Kleerekoper M. The direct examination of three-dimensional bone architecture in vitro by computed tomography. J Bone Miner Res. 1989;4(1):3–11
  18. Ruegsegger P, Koller B, Muller R. A microtomographic system for the nondestructive evaluation of bone architecture. Calcif Tissue Int. 1996;58(1):24–29
  19. Badea C, Hedlund LW, Johnson GA. Micro-CT with respiratory and cardiac gating. Med Phys. 2004;31(12):3324–3329
  20. Takahashi M, Wehrli FW, Hilaire L, Zemel BS, Hwang SN. In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure. Proc Natl Acad Sci USA. 2002;99(7):4574–4579
  21. Takahashi M, Hackney DB, Zhang G, et al. Magnetic resonance microimaging of intraaxonal water diffusion in live excised lamprey spinal cord. Proc Natl Acad Sci USA. 2002;99(25):16192–16196
  22. Takahashi M, Uematsu H, Hatabu H. MR imaging at high magnetic fields. Eur J Radiol. 2003;46(1):45–52
  23. Callaghan PT. Principles of nuclear magnetic resonance microscopy. Oxford: Clarendon Press; 1991;
  24. Wehrli FW, Ford JC, Chung HW, et al. Potential role of nuclear magnetic resonance for the evaluation of trabecular bone quality. Calcif Tissue Int. 1993;53(Suppl 1):S162–S169
  25. Bottomley PA, Andrew ER. RF magnetic field penetration, phase shift and power dissipation in biological tissue: implications for NMR imaging. Phys Med Biol. 1978;23(4):630–643
  26. Beckmann N, Tigani B, Ekatodramis D, Borer R, Mazzoni L, Fozard JR. Pulmonary edema induced by allergen challenge in the rat: noninvasive assessment by magnetic resonance imaging. Magn Reson Med. 2001;45(1):88–95
  27. Tigani B, Schaeublin E, Sugar R, Jackson AD, Fozard JR, Beckmann N. Pulmonary inflammation monitored noninvasively by MRI in freely breathing rats. Biochem Biophys Res Commun. 2002;292(1):216–221
  28. Tigani B, Cannet C, Zurbrugg S, et al. Resolution of the oedema associated with allergic pulmonary inflammation in rats assessed noninvasively by magnetic resonance imaging. Br J Pharmacol. 2003;140(2):239–246
  29. Karmouty-Quintana H, Cannet C, Sugar R, Fozard JR, Page CP, Beckmann N. Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging. Br J Pharmacol. 2007;150(8):1022–1030
  30. Garbow JR, Zhang Z, You M. Detection of primary lung tumors in rodents by magnetic resonance imaging. Cancer Res. 2004;64(8):2740–2742
  31. Marzola P, Lanzoni A, Nicolato E, et al. (1)H MRI of pneumococcal pneumonia in a murine model. J Magn Reson Imag. 2005;22(1):170–174
  32. Kubo S, Levantini E, Kobayashi S, et al. Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice. Magn Reson Med. 2006;56(3):698–703
  33. Li D, Ji H, Zaghlul S, et al. Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas. J Clin Invest. 2007;117(2):346–352
  34. Li D, Shimamura T, Ji H, et al. Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell. 2007;12(1):81–93
  35. Gewalt SL, Glover GH, Hedlund LW, Cofer GP, MacFall JR, Johnson GA. MR microscopy of the rat lung using projection reconstruction. Magn Reson Med. 1993;29(1):99–106
  36. Port RE, Knopp MV, Brix G. Dynamic contrast-enhanced MRI using Gd-DTPA: interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors. Magn Reson Med. 2001;45(6):1030–1038
  37. Uematsu H, Takahashi M, Dougherty L, Hatabu H. High field body MR imaging: preliminary experiences. Clin Imag. 2004;28(3):159–162
  38. Drevs J, Hofmann I, Hugenschmidt H, et al. Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model. Cancer Res. 2000;60(17):4819–4824
  39. Rosen Y, Ramniceanu G, Margalit R, et al. Vascular perfusion of human lung cancer in a rat orthotopic model using dynamic contrast-enhanced magnetic resonance imaging. Int J Cancer. 2006;119(2):365–372
  40. Muruganandham M, Lupu M, Dyke JP, et al. Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast-enhanced MRI at 1.5T. Mol Cancer Ther. 2006;5(8):1950–1957
  41. Altes TA, Mata J, de Lange EE, Brookeman JR, Mugler JP. Assessment of lung development using hyperpolarized helium-3 diffusion MR imaging. J Magn Reson Imag. 2006;24(6):1277–1283
  42. Chen XJ, Moller HE, Chawla MS, et al. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2). Magn Reson Med. 1999;42(4):729–737
  43. Viallon M, Cofer GP, Suddarth SA, et al. Functional MR microscopy of the lung using hyperpolarized 3He. Magn Reson Med. 1999;41(4):787–792
  44. Wagshul ME, Button TM, Li HF, et al. In vivo MR imaging and spectroscopy using hyperpolarized 129Xe. Magn Reson Med. 1996;36(2):183–191
  45. Zhao L, Mulkern R, Tseng CH, et al. Gradient-echo imaging considerations for hyperpolarized 129Xe MR. J Magn Reson B. 1996;113(2):179–183
  46. Dugas JP, Garbow JR, Kobayashi DK, Conradi MS. Hyperpolarized (3)He MRI of mouse lung. Magn Reson Med. 2004;52(6):1310–1317
  47. Chen XJ, Hedlund LW, Moller HE, Chawla MS, Maronpot RR, Johnson GA. Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. Proc Natl Acad Sci USA. 2000;97(21):11478–11481
  48. Grassino AE, Roussos C. Static properties of the lung and chest wall. The lung. Philadelphia: Lippincott-Raven: Scientific Foundations; 1997;pp. 1187–1201
  49. D’Angelo E. Stress-strain relationships during uniform and non-uniform expansion of isolated lungs. Respir Physiol. 1975;23(1):87–107
  50. Proctor DF, Caldini P, Permutt S. The pressure surrounding the lungs. Respir Physiol. 1968;5(1):130–144
  51. West JB. Distribution of mechanical stress in the lung, a possible factor in localisation of pulmonary disease. Lancet. 1971;1(7704):839–841
  52. West JB, Matthews FL. Stresses, strains, and surface pressures in the lung caused by its weight. J Appl Physiol. 1972;32(3):332–345
  53. Clausen JL. The diagnosis of emphysema, chronic bronchitis, and asthma. Clin Chest Med. 1990;11(3):405–416
  54. Takezawa J, Miller FJ, O’Neil JJ. Single-breath diffusing capacity and lung volumes in small laboratory mammals. J Appl Physiol. 1980;48(6):1052–1059
  55. Fujita M, Shannon JM, Irvin CG, et al. Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2001;280(1):L39–L49
  56. Tankersley CG, Rabold R, Mitzner W. Differential lung mechanics are genetically determined in inbred murine strains. J Appl Physiol. 1999;86(6):1764–1769
  57. Gross NJ. Mechanical properties of mouse lungs: effects of degassing on normal, hyperoxic, and irradiated lungs. J Appl Physiol. 1981;51(2):391–398
  58. Heverhagen JT, Hahn HK, Wegmann M, et al. Volumetric analysis of mice lungs in a clinical magnetic resonance imaging scanner. Magma. 2004;17(2):80–85
  59. Wade OL. Movements of the thoracic cage and diaphragm in respiration. J Physiol. 1954;124(2):193–212
  60. Alexander C. Diaphragm movements and the diagnosis of diaphragmatic paralysis. Clin Radiol. 1966;17(1):79–83
  61. Simon G, Bonnell J, Kazantzis G, Waller RE. Some radiological observations on the range of movement of the diaphragm. Clin Radiol. 1969;20(2):231–233
  62. Harris RS, Giovannetti M, Kim BK. Normal ventilatory movement of the right hemidiaphragm studied by ultrasonography and pneumotachography. Radiology. 1983;146(1):141–144
  63. Houston JG, Morris AD, Howie CA, Reid JL, McMillan N. Technical report: quantitative assessment of diaphragmatic movement—a reproducible method using ultrasound. Clin Radiol. 1992;46(6):405–407
  64. Paiva M, Verbanck S, Estenne M, Poncelet B, Segebarth C, Macklem PT. Mechanical implications of in vivo human diaphragm shape. J Appl Physiol. 1992;72(4):1407–1412
  65. Gierada DS, Curtin JJ, Erickson SJ, Prost RW, Strandt JA, Goodman LR. Diaphragmatic motion: fast gradient-recalled-echo MR imaging in healthy subjects. Radiology. 1995;194(3):879–884
  66. Suga K, Tsukuda T, Awaya H, et al. Impaired respiratory mechanics in pulmonary emphysema: evaluation with dynamic breathing MRI. J Magn Reson Imag. 1999;10(4):510–520
  67. Iwasawa T, Kagei S, Gotoh T, et al. Magnetic resonance analysis of abnormal diaphragmatic motion in patients with emphysema. Eur Respir J. 2002;19(2):225–231
  68. Kiryu S, Loring SH, Mori Y, Rofsky NM, Hatabu H, Takahashi M. Quantitative analysis of the velocity and synchronicity of diaphragmatic motion: dynamic MRI in different postures. Magn Reson Imag. 2006;24(10):1325–1332
  69. Zerhouni EA, Parish DM, Rogers WJ, Yang A, Shapiro EP. Human heart: tagging with MR imaging—a method for noninvasive assessment of myocardial motion. Radiology. 1988;169(1):59–63
  70. Axel L, Dougherty L. Heart wall motion: improved method of spatial modulation of magnetization for MR imaging. Radiology. 1989;172(2):349–350
  71. Axel L, Dougherty L. MR imaging of motion with spatial modulation of magnetization. Radiology. 1989;171(3):841–845
  72. Chen Q, Mai VM, Bankier AA, Napadow VJ, Gilbert RJ, Edelman RR. Ultrafast MR grid-tagging sequence for assessment of local mechanical properties of the lungs. Magn Reson Med. 2001;45(1):24–28
  73. Napadow VJ, Mai V, Bankier A, Gilbert RJ, Edelman R, Chen Q. Determination of regional pulmonary parenchymal strain during normal respiration using spin inversion tagged magnetization MRI. J Magn Reson Imag. 2001;13(3):467–474
  74. Voorhees A, An J, Berger KI, Goldring RM, Chen Q. Magnetic resonance imaging-based spirometry for regional assessment of pulmonary function. Magn Reson Med. 2005;54(5):1146–1154
  75. Gee J, Sundaram T, Hasegawa I, Uematsu H, Hatabu H. Characterization of regional pulmonary mechanics from serial magnetic resonance imaging data. Acad Radiol. 2003;10(10):1147–1152
  76. Kiryu S, Sundaram TA, Kubo S, et al. MRI assessment of lung mechanics: in normal mice and the sickle cell disease transgenic mice. J Magn Reson Imaging; in press.
  77. Kubo S, Sundaram TA, Gee JC, Hatabu H, Takahashi M. Four-dimensional volumetric analysis of the lung over respiratory cycle in ventilated mice. In: Proceedings of The 14th Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine. Seattle, WS. 2006;
  78. Takahashi M, Kubo S, Sundaram TA, Gee JC, Hatabu H. Four-dimensional MR microscopy of respiratory mechanics in transgenic mice with emphysema: lung motion quantification via a non-rigid registration algorithm. In: Fifteenth Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine. Berlin, Germany. 2007;

PII: S0720-048X(07)00392-0

doi: 10.1016/j.ejrad.2007.08.011

European Journal of Radiology
Volume 64, Issue 3 , Pages 367-374 , December 2007