European Journal of Radiology
Volume 64, Issue 3 , Pages 335-344 , December 2007

Hyperpolarized 129Xe MRI: A viable functional lung imaging modality?

  • Samuel Patz

      Affiliations

    • Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States
    • Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States
    • Corresponding Author InformationCorresponding author at: Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States. Tel.: +1 617 278 0616; fax: +1 617 278 0610.
  • ,
  • F. William Hersman

      Affiliations

    • Department of Physics, University of New Hampshire, 131 Main Street, Nesmith Hall, Durham, NH 03824, United States
  • ,
  • Iga Muradian

      Affiliations

    • Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States
    • Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States
  • ,
  • Mirko I. Hrovat

      Affiliations

    • Mirtech, Inc., 452 Ash Street, Brockton, MA 02301, United States
  • ,
  • Iulian C. Ruset

      Affiliations

    • Department of Physics, University of New Hampshire, 131 Main Street, Nesmith Hall, Durham, NH 03824, United States
  • ,
  • Stephen Ketel

      Affiliations

    • Department of Physics, University of New Hampshire, 131 Main Street, Nesmith Hall, Durham, NH 03824, United States
  • ,
  • Francine Jacobson

      Affiliations

    • Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States
  • ,
  • George P. Topulos

      Affiliations

    • Department of Anesthesiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States
  • ,
  • Hiroto Hatabu

      Affiliations

    • Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States
    • Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States
  • ,
  • James P. Butler

      Affiliations

    • Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, United States

Received 30 July 2007 ,Revised 31 July 2007 ,Accepted 1 August 2007.

References 

  1. Hyperpolarized Gas Study Group Meeting . In: ISMRM fifteenth scientific meeting. Berlin. 2007;
  2. Hersman FW, Leuschner M, Carberry J. Apparatus and methods for polarizing polarizable nuclear species. US Patent 6,949,169 (September 27, 2005).
  3. Ruset IC, Ketel S, Hersman FW. Optical pumping system design for large production of hyperpolarized. Phys Rev Lett 2006;96(5):053002. Epub 2006 Feb 9.
  4. Zhu H, Ruset IC, Hersman FW. Opt Lett. 2005;30(11):1342–1344
  5. Latchaw RE, Yonas H, Pentheny SL, Gur D. CT cerebral blood flow determination. Radiology. 1987;163:251–254
  6. Mugler JP, Driehuys B, Brookeman JR, et al. MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results. Magn Reson Med. 1997;37(6):809–815
  7. Mugler JP, Mata JF, Wang H-TJ , et al. The apparent diffusion coefficient of 129Xe in the lung: preliminary results. In: Proceedings of the 11th international society on magnetic resonance in medicine. 2004;p. 769
  8. Yonas H, Grundy B, Gur D, Shabason L, Wolfson SK, Cook EE. Side effects of xenon inhalation. J Comput Assist Tomogr. 1981;5(4):591–592
  9. Butler JP, Mair RW, Hoffmann D, et al. Measuring surface-area-to-volume ratios in soft porous materials using laser-polarized xenon interphase exchange NMR. J Phys Condens. 2002;14(13):L297–L304
  10. Patz S, Muradian I, Hrovat MI, et al. Hyperpolarized 129Xe human gas exchange at 0.2T with XTC. In: Proceedings of the 14th annual international society on magnetic resonance in medicine. Seattle, May. 2006;p. 192
  11. Patz S, Muradian I, Hrovat MI, et al. Human pulmonary imaging and spectroscopy with hyperpolarized 129Xe at 0.2T. Acad Radiol, in press.
  12. Ruppert K, Brookeman JR, Hagspiel KD, Mugler JP. Probing lung physiology with xenon polarization transfer contrast (XTC). Magn Reson Med. 2000;44(3):349–357
  13. Ruppert K, Mata JF, Brookeman JR, Hagspiel KD, Mugler JP. Exploring lung function with hyperpolarized 129Xe nuclear magnetic resonance. Magn Reson Med. 2004;51(4):676–687
  14. Mansson S, Wolber J, Driehuys B, et al. Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccharide disease model using hyperpolarized 129Xe. Magn Reson Med. 2003;50(6):1170–1179
  15. Driehuys B, Cofer GP, Pollaro J, et al. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. PNAS. 2006;103(48):18278–18283
  16. Eger EL, Larson CP. Anaesthetic solubility in blood and tissues: values and significance. Brit J Anaesth. 1964;36:140–144
  17. Sta MN, Eckmann DM. Model predictions of gas embolism growth and reabsorption during xenon anesthesia. Anesthesiology. 2003;99(3):638–645
  18. Muradian I, Butler JP, Hrovat M, et al. Human pulmonary gas exchange with xenon polarization transfer contrast (XTC). Magn Reson Med, submitted for publication.
  19. Jameson CJ, Jameson AK, Hwang JK. Nuclear spin relaxation by intermolecular magnetic dipole coupling in the gas phase. 129Xe in oxygen. J Chem Phys. 1988;89(7):4074–4081
  20. Saam B, Happer W, Middleton H. Nuclear relaxation of 3He in the presence of O2. Phys Rev A. 1995;52(1):862–865
  21. Eberle B, Weiler N, Markstaller K, et al. Analysis of intrapulmonary O2 concentration by MR imaging of inhaled hyperpolarized helium-3. J Appl Physiol. 1999;87(6):2043–2052
  22. Deninger AJ, Eberle B, Ebert M, et al. Quantification of regional intrapulmonary oxygen partial pressure evolution during apnea by 3He MRI. J Magn Res. 1999;141(2):207–216
  23. Deninger AJ, Eberle B, Ebert M, et al. 3He-MRI-based measurements of intrapulmonary pO2 and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations. NMR Biomed. 2000;13(4):194–201
  24. Deninger AJ, Eberle B, Bermuth J, et al. Assessment of a single-acquisition imaging sequence for oxygen-sensitive 3He-MRI. Magn Reson Med. 2002;47(1):105–114
  25. Wild JM, Fichele S, Woodhouse N, Paley MN, Kasuboski L, van Beek EJ. 3D volume-localized pO2 measurement in the human lung with 3He MRI. Magn Reson Med. 2005;53(5):1055–1064
  26. Wild JM, Teh K, Woodhouse N, et al. Single scan 3D pO2 mapping with hyperpolarized 3He MRI. ISMRM. 2006;14:869
  27. Hrovat MI, Muradyan I, Ketel S, et al. Human pulmonary pO2 at 0.2T with hyperpolarized 129Xe. ISMRM. 2006;14:1305
  28. West JB. Respiratory physiology, the essentials. 6th ed.. Lippincott Williams & Wilkins; 2000;
  29. Mata JF, Altes TA, Cai J, et al. Evaluation of emphysema severity and progression in a rabbit model: comparison of hyperpolarized 3He and 129Xe diffusion MRI with lung morphometry. J Appl Physiol. 2007;102(3):1273–1280

 Grant support: NIH RO1 HL73632, RR14297, HL67784, EB02553, RR20200, HL78285, HL82013, ES14005, HL87550.

PII: S0720-048X(07)00387-7

doi: 10.1016/j.ejrad.2007.08.008

European Journal of Radiology
Volume 64, Issue 3 , Pages 335-344 , December 2007