European Journal of Radiology
Volume 64, Issue 3 , Pages 320-328, December 2007

Basics concepts and clinical applications of oxygen-enhanced MR imaging

  • Yoshiharu Ohno

      Affiliations

    • Department of Radiology, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 78 382 6104; fax: +81 78 382 6129.
    • ,
  • Hiroto Hatabu

      Affiliations

    • Department of Radiology and Center for Pulmonary Functional Imaging, Brigham Women's Hospital, Harvard Medical Center, 75 Francis Street, Boston, MA 02115, USA

Received 30 July 2007; received in revised form 31 July 2007; accepted 1 August 2007.

Abstract 

Oxygen-enhanced MR imaging is a new technique, and its physiological significance has not yet been fully elucidated. This review article covers (1) the theory of oxygen enhancement and its relationship with respiratory physiology; (2) design for oxygen-enhanced MR imaging sequencing; (3) a basic study of oxygen-enhanced MR imaging in animal models and humans; (4) a clinical study of oxygen-enhanced MR imaging; and (5) a comparison of advantages and disadvantages of this technique with those of hyperpolarized noble gas MR ventilation imaging.

Oxygen-enhanced MR imaging provides not only the ventilation-related, but also respiration-related information. Oxygen-enhanced MR imaging has the potential to replace nuclear medicine studies for the identification of regional pulmonary function, and many investigators are now attempting to adapt this technique for routine clinical studies.

We believe that further basic studies as well as clinical applications of this new technique will define the real significance of oxygen-enhanced MR imaging for the future of pulmonary functional imaging and its usefulness for diagnostic radiology and pulmonary medicine.

Keywords: Magnetic resonance, Lung, Ventilation, Oxygen, Pulmonary function

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PII: S0720-048X(07)00384-1

doi:10.1016/j.ejrad.2007.08.006

European Journal of Radiology
Volume 64, Issue 3 , Pages 320-328, December 2007

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