European Journal of Radiology
Volume 63, Issue 1 , Pages 120-123 , July 2007

Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography

  • Joern J.W. Sandstede

      Affiliations

    • Department of Radiology, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany
    • Roentgenzentrum Hamburg, Schaeferkampsallee 5-7, D-20357 Hamburg, Germany
    • Corresponding Author InformationCorresponding author at: Roentgenzentrum Hamburg, Schaeferkampsallee 5-7, 20357 Hamburg, Germany. Tel.: +49 40 547374700; fax: +49 40 547374770.
    • ,
  • Anne Roth

      Affiliations

    • Department of Radiology, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany
    • ,
  • Wolfram Machann

      Affiliations

    • Department of Radiology, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany
    • ,
  • Christine Kaupert

      Affiliations

    • Department of Radiology, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany
    • ,
  • Dietbert Hahn

      Affiliations

    • Department of Radiology, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany

Received 10 October 2006 ,Revised 18 January 2007 ,Accepted 19 January 2007.

References 

  1. Aspelin P, Aubry P, Fransson S-G, Strasser R, Willenbrock R, Berg KJ. Nephrotoxicity in high-risk patients study of iso-osmolar and low-osmolar non-ionic contrast media study I nephrotoxic effects in high-risk patients undergoing angiography. N Engl J Med. 2003;348:491–499
  2. McCullough PA, Bertrand ME, Brinker JA, Stacul F. A meta-analysis of the renal safety of isosmolar iodixanol compared with low-osmolar contrast media. J Am Coll Cardiol. 2006;48:692–699
  3. Becker CR, Reiser MF. Use of iso-osmolar nonionic dimeric contrast media in multidetector row computed tomography angiography for patients with renal impairment. Invest Radiol. 2005;40:672–675
  4. Petrik M, Weigel C, Kirsch M, Hosten N. No detectable nephrotoxic side effect using a dimer, non-ionic contrast media in cerebral perfusion computed tomography in case of suspected brain ischemia. Rofo. 2005;177:1242–1249
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  7. Finn WF. The clinical and renal consequences of contrast-induced nephropathy. Nephrol Dial Transplant. 2006;21:i2–i10
  8. Rich MW, Crecelius CA. Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study. Arch Intern Med. 1990;150:1237–1242
  9. Soma VR, Cavusoglu E, Vidhun R, Frishman WH, Sharma SK. Contrast-associated nephropathy. Heart Dis. 2002;4:372–379
  10. Thomsen HS, Morcos SK. Contrast-medium-induced nephropathy: is there a new consensus? A review of published guidelines. Eur Radiol. 2006;16:1835–1840
  11. Lameire N. Contrast-induced nephropathy—prevention and risk reduction. Nephrol Dial Transplant. 2006;21:i11–i23
  12. Schild HH, Kuhl CK, Hubner-Steiner U, Bohm I, Speck U. Adverse events after unenhanced and monomeric and dimeric contrast-enhanced CT: a prospective randomized controlled trial. Radiology. 2006;240:56–64
  13. Sutton AG, Finn P, Grech ED, et al. Early and late reactions after the use of iopamidol 340, ioxaglate 320, and iodixanol 320 in cardiac catheterization. Am Heart J. 2001;141:677–683
  14. Sutton AG, Finn P, Campbell PG, et al. Early and late reactions following the use of iopamidol 340, iomeprol 350 and iodixanol 320 in cardiac catheterization. J Invasive Cardiol. 2003;15:133–138
  15. Fransson SG, Stenport G, Andersson M. Immediate and late adverse reactions in coronary angiography. A comparison between iodixanol and ioxaglate. Acta Radiol. 1996;37:218–222
  16. Rydberg J, Charles J, Aspelin P. Frequency of late allergy-like adverse reactions following injection of intravascular non-ionic contrast media. A retrospective study comparing a non-ionic monomeric contrast medium with a non-ionic dimeric contrast medium. Acta Radiol. 1998;39:219–222
  17. Webb JA, Stacul F, Thomsen HS, Morcos SK. Late adverse reactions to intravascular iodinated contrast media. Eur Radiol. 2003;13:181–184

PII: S0720-048X(07)00044-7

doi: 10.1016/j.ejrad.2007.01.021

European Journal of Radiology
Volume 63, Issue 1 , Pages 120-123 , July 2007

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