European Journal of Radiology
Volume 62, Issue 2 , Pages 247-256 , May 2007

Usage of the T1 effect of an iron oxide contrast agent in an animal model to quantify myocardial blood flow by MRI

  • Lutz Lüdemann

      Affiliations

    • Department of Radiology and Nuclear Medicine Charité—Universitätmedizin Berlin, Campus Virchow-Klinikum, Germany
    • They contributed equally to this work.
    • Corresponding Author InformationCorresponding author at: Charité, Campus Virchow-Klinikum, Berlin, Strahlenklinik, Augustenburger Platz 1, 13353 Berlin, Germany. Tel.: +49 30 450557188; fax: +49 30 450557979.
    • ,
  • Boris Schmitt

      Affiliations

    • Department of Congenital Heart Disease, Deutsches Herzzentrum, Berlin, Germany
    • They contributed equally to this work.
    • ,
  • Petr Podrabsky

      Affiliations

    • Department of Radiology and Nuclear Medicine Charité—Universitätmedizin Berlin, Campus Virchow-Klinikum, Germany
    • ,
  • Bernhard Schnackenburg

      Affiliations

    • Philips Medical Systems, Hamburg, Germany
    • ,
  • Johannes Böck

      Affiliations

    • Department of Radiology and Nuclear Medicine Charité—Universitätmedizin Berlin, Campus Virchow-Klinikum, Germany
    • ,
  • Matthias Gutberlet

      Affiliations

    • Department of Radiology and Nuclear Medicine Charité—Universitätmedizin Berlin, Campus Virchow-Klinikum, Germany

Received 28 July 2006 ,Revised 30 November 2006 ,Accepted 1 December 2006.

References 

  1. Schwartz JG, Johnson RB, Aepfelbacher FC, et al. Sensitivity, specificity and accuracy of stress SPECT myocardial perfusion imaging for detection of coronary artery disease in the distribution of first-order branch vessels, using an anatomical matching of angiographic and perfusion data. Nucl Med Commun. 2003;24:543–549
  2. Gewirtz H, Fischman AJ, Abraham S, Gilson M, Strauss HW, Alpert NM. Positron emission tomographic measurements of absolute regional myocardial blood flow permits identification of nonviable myocardium in patients with chronic myocardial infarction. J Am Coll Cardiol. 1994;23:851–859
  3. Pirich C, Leber A, Knez A, et al. Relation of coronary vasoreactivity and coronary calcification in asymptomatic subjects with a family history of premature coronary artery disease. Eur J Nucl Med Mol Imaging. 2004;31:663–670
  4. Jerosch-Herold M, Swingen C, Seethamraju RT. Myocardial blood flow quantification with MRI by model-independent deconvolution. Med Phys. 2002;29:886–897
  5. Schmitt M, Viallon M, Thelen M, Schreiber WG. Quantification of myocardial blood flow and blood flow reserve in the presence of arterial dispersion: a simulation study. Magn Reson Med. 2002;47:787–793
  6. Vallee JP, Sostman HD, MacFall JR, Coleman RE. Quantification of myocardial perfusion with MRI and exogenous contrast agents. Cardiology. 1997;88:90–105
  7. Al-Saadi N, Gross M, Bornstedt A, et al. Comparison of various parameters for determining an index of myocardial perfusion reserve in detecting coronary stenosis with cardiovascular magnetic resonance tomography. Z Kardiol. 2001;90:824–834
  8. Canet EP, Janier MF, Revel D. Magnetic resonance perfusion imaging in ischemic heart disease. J Magn Reson Imaging. 1999;10:423–433
  9. Jerosch-Herold M, Wilke N, Wang Y, et al. Direct comparison of an intravascular and an extracellular contrast agent for quantification of myocardial perfusion. Cardiac MRI Group. Int J Card Imaging. 1999;15:453–464
  10. Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999;10:223–232
  11. Christian TF, Rettmann DW, Aletras AH, et al. Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging. Radiology. 2004;232:677–684
  12. Wacker CM, Bauer WR. Myocardial microcirculation in humans—new approaches using MRI. Herz. 2003;28:74–81
  13. Hamm B, Staks T, Taupitz M, et al. Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide. J Magn Reson Imaging. 1994;4:659–668
  14. Kety SS. Theory of blood-tissue exchange and its application to measurement of blood flow. Methods Med Res. 1960;8:223–227
  15. Kety SS, Schmidt CF. The nitrous oxide method for the quantitative determination of cerebral blood flow in man. Theory, procedure and normal values. J Clin Invest. 1948;27:476–483
  16. Rosen BR, Belliveau JW, Vevea JM, Brady TJ. Perfusion imaging with NMR contrast agents. Magn Reson Med. 1990;14:249–265
  17. Carme SW, Wiart M, Larsson M, Neyran B, Canet-Soulas, E. Effects of water exchange on MR quantification of regional myocardial blood flow using an intravascular T1 contrast agent. Paper presented at the ISMRM Twelfth Scientific Meeting, Kyoto; 2004.
  18. Donahue KM, Weisskoff RM, Parmelee DJ, et al. Dynamic Gd-DTPA enhanced MRI measurement of tissue cell volume fraction. Magn Reson Med. 1995;34:423–432
  19. Wendland MF, Saeed M, Yu KK, et al. Inversion recovery EPI of bolus transit in rat myocardium using intravascular and extravascular gadolinium-based MR contrast media: dose effects on peak signal enhancement. Magn Reson Med. 1994;32:319–329
  20. Schmitt M, Horstick G, Petersen S, et al. Quantification of resting myocardial blood flow in a pig model of acute ischemia based on first-pass MRI. Magn Reson Med. 2005;53:1223–1227
  21. du Toit E, Hofmann D, McCarthy J, Pineda C. Effect of levosimendan on myocardial contractility, coronary and peripheral blood flow, and arrhythmias during coronary artery ligation and reperfusion in the in vivo pig model. Heart. 2001;86:81–87
  22. Yip G, Khandheria B, Belohlavek M, et al. Strain echocardiography tracks dobutamine-induced decrease in regional myocardial perfusion in nonocclusive coronary stenosis. J Am Colloid Cardiol. 2004;44:1664–1671
  23. Lindner KH, Prengel AW, Pfenninger EG, et al. Vasopressin improves vital organ blood flow during closed-chest cardiopulmonary resuscitation in pigs. Circulation. 1995;91:215–221
  24. Altura BM, Halevy S. Cardiovascular actions of anesthetics and drugs used in aesthesia. vols. I and II. Basel: Kager; 1986;
  25. Doenicke A. Etomidate: Anästesiologie und Wiederbelebung. vol. 106. Berlin: Springer; 1977;
  26. Schüttler J, Stoeckel H, Wilms M, Schwilden H, Lauven PM. Infusion model for etomidate. Anaesthesist. 1980;29(12):662–666
  27. Duman A, Saide Sahin A, Esra Atalik K, et al. The in vitro effects of remifentanil and fentanyl on isolated human right atria and saphenous veins. J Cardiothorac Vasc Anesth. 2003;17:465–469
  28. Yellon DM, Downey JM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev. 2003;83(4):1113–1151
  29. Raeburn CD, Zimmerman MA, Arya J, Barsness K, Harken AH. Ischemic preconditioning: fact or fantasy?. J Card Surg. 2002;17:536–542
  30. Kowallik P, Schulz R, Guth BD, et al. Measurement of regional myocardial blood flow with multiple colored microspheres. Circulation. 1991;83:974–982
  31. Grund F, Sommerschild HT, Lyberg T, Kirkeboen KA, Ilebekk A. Microembolization in pigs: effects on coronary blood flow and myocardial ischemic tolerance.. Am J Physiol. 1999;277(2 Pt 2):H533–H542
  32. Millard RW, Baig H, Vatner SF. Cardiovascular effects of radioactive microsphere suspensions and Tween 80 solutions. Am J Physiol. 1977;232(3):H331–H334
  33. Crnac J, Schmidt MC, Theissen P, Sechtem U. Assessment of myocardial perfusion by magnetic resonance imaging. Herz. 1997;22:16–28
  34. Jerosch Herold M, Hu X, Murthy NS, Rickers C, Stillman AE. Magnetic resonance imaging of myocardial contrast enhancement with MS-325 and its relation to myocardial blood flow and the perfusion reserve. J Magn Reson Imaging. 2003;18:544–554
  35. Kraitchman DL, Wilke N, Hexeberg E, et al. Myocardial perfusion and function in dogs with moderate coronary stenosis. Magn Reson Med. 1996;35:771–780
  36. Machnig T, Koroneos A, Engels G, et al. Quantitative evaluation of myocardial perfusion with ultrafast magnetic resonance tomography. Z Kardiol. 1994;83:840–850
  37. Canet E, Revel D, Forrat R, et al. Superparamagnetic iron oxide particles and positive enhancement for myocardial perfusion studies assessed by subsecond T1-weighted MRI. Magn Reson Imaging. 1993;11:1139–1145
  38. Canet E, Revel D, Sebbag L, et al. Noninvasive assessment of no-reflow phenomenon in a canine model of reperfused infarction by contrast-enhanced magnetic resonance imaging. Am Heart J. 1995;130:949–956
  39. Lombardi M, Jones RA, Westby J, et al. Use of the mean transit time of an intravascular contrast agent as an exchange-insensitive index of myocardial perfusion. J Magn Reson Imaging. 1999;9:402–408
  40. Revel D, Canet E, Sebbag L, et al. First-pass and delayed magnetic resonance imaging studies of reperfused myocardial infarction with iron oxide particles.. Acad Radiol. 1996;3(Suppl. 2):S398–S401
  41. Taupitz M, Schnorr J, Wagner S, et al. Coronary MR angiography: experimental results with a monomer-stabilized blood pool contrast medium. Radiology. 2002;222:120–126
  42. Wagner S, Schnorr J, Pilgrimm H, Hamm B, Taupitz M. Monomer-coated very small superparamagnetic iron oxide particles as contrast medium for magnetic resonance imaging: preclinical in vivo characterization. Invest Radiol. 2002;37:167–177

PII: S0720-048X(06)00529-8

doi: 10.1016/j.ejrad.2006.12.002

European Journal of Radiology
Volume 62, Issue 2 , Pages 247-256 , May 2007

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