European Journal of Radiology
Volume 62, Issue 2 , Pages 235-246 , May 2007

Sixty-four-MSCT in the characterization of porcine acute and subacute myocardial infarction: Determination of transmurality in comparison to magnetic resonance imaging and histopathology

  • H. Brodoefel

      Affiliations

    • Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 7071 2987212; fax: +49 7071 295845.
    • ,
  • B. Klumpp

      Affiliations

    • Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
    • ,
  • A. Reimann

      Affiliations

    • Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
    • ,
  • M. Fenchel

      Affiliations

    • Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
    • ,
  • M. Heuschmid

      Affiliations

    • Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
    • ,
  • S. Miller

      Affiliations

    • Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
    • ,
  • S. Schroeder

      Affiliations

    • Department of Cardiology, Eberhard-Karls-University, Otfried-Müller-Str. 10, 72076 Tübingen, Germany
    • ,
  • C. Claussen

      Affiliations

    • Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
    • ,
  • A.M. Scheule

      Affiliations

    • Department of Thoracic, Cardiac and Vascular Surgery, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
    • These authors contributed equally.
    • ,
  • A.F. Kopp

      Affiliations

    • Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
    • These authors contributed equally.

Received 19 September 2006 ,Revised 22 November 2006 ,Accepted 24 November 2006.

References 

  1. Beek AM, Kuhl HP, Bondarenko O, et al. Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction. J Am Coll Cardiol. 2003;42:895–901
  2. Hillenbrand HB, Kim RJ, Parker MA, Fieno DS, Judd RM. Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging. Circulation. 2000;102:1678–1683
  3. Kim RJ, Chen EL, Lima JA, Judd RM. Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. Circulation. 1996;94:3318–3326
  4. Mahrholdt H, Wagner A, Judd RM, Sechtem U. Assessment of myocardial viability by cardiovascular magnetic resonance imaging. Eur Heart J. 2002;23:602–619
  5. Burt RW, Perkins OW, Oppenheim BE, et al. Direct comparison of fluorine-18-FDG SPECT, fluorine-18-FDG PET and rest thallium-201 SPECT for detection of myocardial viability. J Nucl Med. 1995;36:176–179
  6. Phelps ME, Hoffman EJ, Selin C, et al. Investigation of [18F]2-fluoro-2-deoxyglucose for the measure of myocardial glucose metabolism. J Nucl Med. 1978;19:1311–1319
  7. Sicari R, Picano E, Landi P, et al. Prognostic value of dobutamine–atropine stress echocardiography early after acute myocardial infarction. Echo Dobutamine International Cooperative (EDIC) Study. J Am Coll Cardiol. 1997;29:254–260
  8. Simonetti OP, Kim RJ, Fieno DS, et al. An improved MR imaging technique for the visualization of myocardial infarction. Radiology. 2001;218:215–223
  9. Wagner A, Mahrholdt H, Holly TA, et al. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet. 2003;361:374–379
  10. Choi KM, Kim RJ, Gubernikoff G, Vargas JD, Parker M, Judd RM. Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation. 2001;104:1101–1107
  11. Wu KC, Zerhouni EA, Judd RM, et al. Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation. 1998;97:765–772
  12. Huber DJ, Lapray JF, Hessel SJ. In vivo evaluation of experimental myocardial infarcts by ungated computed tomography. AJR Am J Roentgenol. 1981;136:469–473
  13. Slutsky RA, Mattrey RF, Long SA, Higgins CB. In vivo estimation of myocardial infarct size and left ventricular function by prospectively gated computerized transmission tomography. Circulation. 1983;67:759–765
  14. Gosalia A, Haramati LB, Sheth MP, Spindola-Franco H. CT detection of acute myocardial infarction. AJR Am J Roentgenol. 2004;182:1563–1566
  15. Hoffmann U, Millea R, Enzweiler C, et al. Acute myocardial infarction: contrast-enhanced multi-detector row CT in a porcine model. Radiology. 2004;231:697–701
  16. Nikolaou K, Knez A, Sagmeister S, et al. Assessment of myocardial infarctions using multidetector-row computed tomography. J Comput Assist Tomogr. 2004;28:286–292
  17. Wada H, Kobayashi Y, Yasu T, et al. Multi-detector computed tomography for imaging of subendocardial infarction: prediction of wall motion recovery after reperfused anterior myocardial infarction. Circ J. 2004;68:512–514
  18. Baks T, Cademartiri F, Moelker AD, et al. Multislice computed tomography and magnetic resonance imaging for the assessment of reperfused acute myocardial infarction. J Am Coll Cardiol. 2006;48:144–152
  19. Buecker A, Katoh M, Krombach GA, et al. A feasibility study of contrast enhancement of acute myocardial infarction in multislice computed tomography: comparison with magnetic resonance imaging and gross morphology in pigs. Invest Radiol. 2005;40:700–704
  20. Gerber BL, Belge B, Legros GJ, et al. Characterization of acute and chronic myocardial infarcts by multidetector computed tomography: comparison with contrast-enhanced magnetic resonance. Circulation. 2006;113:823–833
  21. Koyama Y, Matsuoka H, Mochizuki T, et al. Assessment of reperfused acute myocardial infarction with two-phase contrast-enhanced helical CT: prediction of left ventricular function and wall thickness. Radiology. 2005;235:804–811
  22. Koyama Y, Mochizuki T, Higaki J. Computed tomography assessment of myocardial perfusion, viability, and function. J Magn Reson Imaging. 2004;19:800–815
  23. Lardo AC, Cordeiro MA, Silva C, et al. Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar. Circulation. 2006;113:394–404
  24. Mahnken AH, Koos R, Katoh M, et al. Assessment of myocardial viability in reperfused acute myocardial infarction using 16-slice computed tomography in comparison to magnetic resonance imaging. J Am Coll Cardiol. 2005;45:2042–2047
  25. Paul JF, Wartski M, Caussin C, et al. Late defect on delayed contrast-enhanced multi-detector row CT scans in the prediction of SPECT infarct size after reperfused acute myocardial infarction: initial experience. Radiology. 2005;236:485–489
  26. Cerqueira MD, Weissman NJ, Dilsizian V, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105:539–542
  27. Constantine G, Shan K, Flamm SD, Sivananthan MU. Role of MRI in clinical cardiology. Lancet. 2004;363:2162–2171
  28. Thomson LE, Kim RJ, Judd RM. Magnetic resonance imaging for the assessment of myocardial viability. J Magn Reson Imaging. 2004;19:771–788
  29. Kim RJ, Wu E, Rafael A, et al. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med. 2000;343:1445–1453
  30. Gerber BL, Rochitte CE, Melin JA, et al. Microvascular obstruction and left ventricular remodeling early after acute myocardial infarction. Circulation. 2000;101:2734–2741
  31. Mahnken AH, Bruners P, Katoh M, Wildberger JE, Gunther RW, Buecker A. Dynamic multi-section CT imaging in acute myocardial infarction: preliminary animal experience. Eur Radiol. 2006;16:746–752
  32. Nikolaou K, Sanz J, Poon M, et al. Assessment of myocardial perfusion and viability from routine contrast-enhanced 16-detector-row computed tomography of the heart: preliminary results. Eur Radiol. 2005;15:864–871

☆ This study has been funded by an institutional “Fortune Grant” (Project Number 1500-0-0).

PII: S0720-048X(06)00519-5

doi: 10.1016/j.ejrad.2006.11.031

European Journal of Radiology
Volume 62, Issue 2 , Pages 235-246 , May 2007

Article Tools

* Image Usage & Resolution