European Journal of Radiology
Volume 61, Issue 1 , Pages 33-43 , January 2007

Imaging of hepatic steatosis and fatty sparing

Received 9 October 2006 ,Accepted 2 November 2006.

References 

  1. Mortele KJ, Ros PR. Imaging of diffuse liver disease. Semin Liver Dis. 2001;21:195–212
  2. Siegelman ES, Rosen MA. Imaging of hepatic steatosis. Semin Liver Dis. 2001;21:71–80
  3. Danet IM, Semelka RC, Braga L. MR imaging of diffuse liver disease. Radiol Clin N Am. 2003;41:67–87
  4. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43(Suppl. 1):S99–S112
  5. Hashimoto M, Heianna J, Tate E, et al. Small veins entering the liver. Eur Radiol. 2002;12:2000–2005
  6. Quinn SF, Gosink BB. Characteristic sonographic signs of hepatic fatty infiltration. Am J Roentgenol. 1985;145:753–755
  7. Valls C, Iannacconne R, Alba E, et al. Fat in the liver: diagnosis and characterization. Eur Radiol. 2006;16:2292–2308
  8. Mottin CC, Moretto M, Padoin AV, et al. The role of ultrasound in the diagnosis of hepatic steatosis in morbidly obese patients. Obes Surg. 2004;14:635–637
  9. Joy D, Thava VR, Scott BB. Diagnosis of fatty liver disease: is biopsy necessary?. Eur J Gastroenterol Hepatol. 2003;15:539–543
  10. Palmentieri B, de Sio I, La Mura V, et al. The role of bright liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis. Dig Liver Dis. 2006;38:485–489
  11. Hepburn MJ, Vos JA, Fillman EP, Lawitz EJ. The accuracy of the report of hepatic steatosis on ultrasonography in patients infected with hepatitis C in a clinical setting: a retrospective observational study. BMC Gastroenterol. 2005;5:14
  12. Mathiesen UL, Franzen LE, Aselius H. Increased liver echogenicity at ultrasound examination reflects degreeof steatosis but not of fibrosis in asymptomatic patients with mild/moderate abnormalities of liver transaminases. Dig Liver Dis. 2002;34:516–522
  13. Joseph AEA, Saverymuttu SH, Al-Sam S, Cook MG, Maxwell JD. Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease. Clin Radiol. 1991;43:26–31
  14. Fishbein M, Castro F, Cheruku S, et al. Hepatic MRI for fat quantitation: its relationship to fat morphology, diagnosis, and ultrasound. J Clin Gastroenterol. 2005;39:619–625
  15. Kim SH, Lee JM, Kim JH, et al. Appropriateness of a donor liver with respect to macrosteatosis: application of artificial neural networks to US images—initial experience. Radiology. 2005;234:793–803
  16. Gaitini D, Lederman M, Baruch Y, et al. Computerised analysis of liver texture with correlation to needle biopsy. Ultraschall Med. 2005;26:197–202
  17. Gaitini D, Baruch Y, Ghersin E, et al. Feasibility study of ultrasonic fatty liver biopsy: texture vs. attenuation and backscatter. Ultrasound Med Biol. 2004;30:321–327
  18. Kawata R, Sakata K, Kunieda T, et al. Quantitative evaluation of fatty liver by computed tomography in rabbits. Am J Roentgenol. 1984;142:741–746
  19. Piekarski J, Goldberg HI, Royal SA, Axel L, Moss AA. Difference between liver and spleen CT numbers in the normal adult: its usefulness in predicting the presence of diffuse liver disease. Radiology. 1980;137:727–729
  20. Bydder GM, Kreel L, Chapman RW, et al. Accuracy of computed tomography in diagnosis of fatty liver. BMJ. 1980;281:1042
  21. Iwasaki M, Takada Y, Hayashi M, et al. Noninvasive evaluation of graft steatosis in living donor liver transplantation. Transplantation. 2004;78:1501–1505
  22. Pamilo M, Sotaniemi EA, Suramo I, Lahde S, Arranto AJ. Evaluation of liver steatotic and fibrous content by computerised tomography and ultrasound. Scand J Gastroenterol. 1983;18:743–747
  23. Nishino M, Hayakawa K, Nakamura Y, Morimoto T, Mukaihara S. Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: high frequency of involvement and rapid reversal after completion of tamoxifen therapy. Am J Roentgenol. 2003;180:129–134
  24. Ricci C, Longo R, Gioulis E, et al. Noninvasive in vivo quantitative assessment of fat content in human liver. J Hepatol. 1997;27:108–113
  25. Johnston RJ, Stamm ER, Lewin JM, Hendrick RE, Archer PG. Diagnosis of fatty infiltration of the liver on contrast enhanced CT: limitations of liver-minus-spleen attenuation difference measurements. Abdom Imaging. 1998;23:409–415
  26. Jacobs JE, Birnbaum BA, Shapiro MA, et al. Diagnostic criteria for fatty infiltration of the liver on contrast enhanced helical CT. Am J Roentgenol. 1998;171:659–664
  27. Panicek DM, Giess CS, Schwartz LH. Qualitative assessment of liver for fatty infiltration on contrast enhanced CT: is muscle a better standard of reference than spleen?. J Comput Assist Tomogr. 1997;21:699–705
  28. Mendler MH, Bouillet Le Sidaner A. Dual-energy CT in the diagnosis and quantification of fatty liver: limited clinical value in comparison to ultrasound scan and single energy CT, with special reference to iron overload. J Hepatol. 1998;28:785–794
  29. Wang B, Gao Z, Zou Q, Li L. Quantitative diagnosis of fatty liver with dual-energy CT. An experimental study in rabbits. Acta Radiol. 2003;44:92–97
  30. Raptopoulos V, Karellas A, Bernstein J, et al. Value of dual-energy CT in differentiating focal fatty infiltration of the liver from low-density masses. Am J Roentgenol. 1991;157:721–725
  31. Kamel IR, Kruskal JB, Pomfret EA, et al. Impact of multidetector CT on donor selection and surgical planning before living adult right lobe liver transplantation. Am J Roentgenol. 2001;176:193–200
  32. Flohr TG, McCollough CH, Bruder H, et al. First performance evaluation of a dual-source CT (DSCT) system. Eur Radiol. 2006;16:256–268
  33. Park SH, Kim PN, Kim KW, et al. Macrovesicular hepatic steatosis in living liver donors: use of CT for quantitative and qualitative assessment. Radiology. 2006;239:105–112
  34. Brancatelli G. Science to practice: should biopsy be performed in potential liver donors when unenhanced CT shows an unacceptable degree of steatosis for transplantation?. Radiology. 2006;239:1–2
  35. Limanond P, Raman SS, Lassman C, et al. Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings. Radiology. 2004;230:276–280
  36. Fritz GA, Schoellnast H, Deutschmann HA, et al. Density histogram analysis of unenhanced hepatic computed tomography in patients with diffuse liver diseases. J Comput Assist Tomogr. 2006;30:201–205
  37. Levenson H, Greensite F, Hoefs J, et al. Fatty infiltration of the liver: quantification with phase-contrast MR imaging at 1.5T vs biopsy. Am J Roentgenol. 1991;156:307–312
  38. Mitchell DG, Kim I, Chang TS, et al. Fatty liver: chemical shift phase-difference and suppression magnetic resonance imaging techniques in animals, phantoms, and humans. Invest Radiol. 1991;26:1041–1052
  39. Outwater EK, Blasbalg R, Siegelman ES, Vala M. Detection of lipid in abdominal tissues with opposed-phase gradientecho images at 1.5T: techniques and diagnostic importance. Radiographics. 1998;18:1465–1480
  40. Fishbein MH, Gardner KG, Potter CJ, Schmalbrock P, Smith MA. Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging. 1997;15:287–293
  41. Pilleul F, Chave G, Dumortier J, Scoazec JY, Valette PJ. Fatty infiltration of the liver. Detection and grading using dual T1 gradient echo sequences on clinical MR system. Gastroenterol Clin Biol. 2005;29:1143–1147
  42. Kim SH, Lee JM, Han JK, et al. Hepatic macrosteatosis: predicting appropriateness of liver donation by using MR imaging—correlation with histopathologic findings. Radiology. 2006;240:116–129
  43. Rinella ME, McCarthy R, Thakrar K, et al. Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: implications for living liver donation. Liver Transpl. 2003;9:851–856
  44. Hussain HK, Chenevert TL, Londy FJ, et al. Hepatic fat fraction: MR imaging for quantitative measurement and display—early experience. Radiology. 2005;237:1048–1055
  45. Qayyum A, Goh JS, Kakar S, et al. Accuracy of liver fat quantification at MR imaging: comparison of out of phase gradient-echo and fat-saturated fast spin–echo technique—initial experience. Radiology. 2005;237:507–511
  46. Longo R, Ricci C, Masutti F, et al. Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography. Invest Radiol. 1993;28:297–302
  47. Thomsen C, Becker U, Winkler K, et al. Quantification of liver fat using magnetic resonance spectroscopy. Magn Reson Imaging. 1994;12:487–495
  48. Machann J, Thamer C, Schnoedt B, et al. Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy. Magn Reson Med. 2006;55:913–917
  49. Saadeh S, Younossi ZM, Remer EM, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002;123:745–750
  50. Duman DG, Celikel C, Tuney D, et al. Computed tomography in nonalcoholic fatty liver disease: a useful tool for hepatosteatosis assessment?. Dig Dis Sci. 2006;51:346–351
  51. Oliva MR, Mortele KJ, Segatto E, et al. Computed tomography features of nonalcoholic steatohepatitis with histopathologic correlation. J Comput Assist Tomogr. 2006;30:37–43
  52. Tsushima Y, Endo K. Spleen enlargement in patients with nonalcoholic fatty liver: correlation between degree of fatty infiltration in liver and size of spleen. Dig Dis Sci. 2000;45:196–200
  53. Mihmanli I, Kantarci F, Yilmaz MH, et al. Effect of diffuse fatty infiltration of the liver on hepatic artery resistance index. J Clin Ultrasound. 2005;33:95–99
  54. Oguzkurt L, Yildirim T, Torun D, et al. Hepatic vein Doppler waveform in patients with diffuse fatty infiltration of the liver. Eur J Radiol. 2005;54:253–257
  55. Lee VS, Morgan GR, Teperman LW, et al. MR imaging as the sole preoperative imaging modality for right hepatectomy: a prospective study of living adult-to-adult liver donor candidates. Am J Roentgenol. 2001;176:1475–1482
  56. Schroeder T, Malago M, Debatin JF, et al. “All-in-one” imaging protocols for the evaluation of potential livingliver donors: comparison of magnetic resonance imaging and multidetector computed tomography. Liver Transpl. 2005;11:776–787
  57. Cho JY, Suh KS, Kwon CH, Yi NJ, Lee KU. Mild hepatic steatosis is not a major risk factor for hepatectomy and regenerative power is not impaired. Surgery. 2006;139:508–515
  58. Soejima Y, Shimada M, Suehiro T, et al. Use of steatotic graft in living-donor liver transplantation. Transplantation. 2003;76:344–348
  59. Kemper J, Jung G, Poll LW. CT and MRI findings of multifocal hepatic steatosis mimicking malignancy. Abdom Imaging. 2002;27:708–710
  60. Kroncke TJ, Taupitz M, Kivelitz D, et al. Multifocal nodular fatty infiltration of the liver mimicking metastatic disease on CT: imaging findings and diagnosis using MR imaging. Eur Radiol. 2000;10:1095–1100
  61. Kammen BF, Pacharn P, Thoeni RF. Focal fatty infiltration of the liver: analysis of prevalence and CT findings in children and young adults. Am J Roentgenol. 2001;177:1035–1039
  62. Koseoglu K, Ozsunar Y, Taskin F, Karaman C. Pseudolesions of left liver lobe during helical CT examinations: prevalence and comparison between unenhanced and biphasic CT findings. Eur J Radiol. 2005;54:388–392
  63. Yoshikawa J, Matsui O, Takashima T, et al. Focal fatty change of the liver adjacent to falciform ligament: CT and sonographic findings in five surgically confirmed cases. Am J Roentgenol. 1987;149:491–494
  64. Soyer P, Dewine N, Someville E, et al. Hepatic pseudolesion around the falciform ligament: prevalence on CT examination. Abdom Imaging. 1996;21:324–328
  65. Itai Y, Matsui O. Blood flow and liver imaging. Radiology. 1997;202:306–314
  66. Matsui O, Kadoya M, Takahashi S, et al. Focal sparing of segment IV in fatty livers shown by sonography and CT: correlation with aberrant gastric venous drainage. Am J Roentgenol. 1995;164:1137–1140
  67. Arai K, Matsui O, Takashima T, Ida M, Nishida Y. Focal spared areas in fatty liver caused by regional decreased portal flow. Am J Roentgenol. 1988;151:300–302
  68. Basaran C, Karcaaltincaba M, Akata D, et al. Fat-containing lesions of the liver: cross-sectional imaging findings with emphasis on MRI. Am J Roentgenol. 2005;184:1103–1110
  69. Sohn J, Siegelman E, Osiason A. Unusual patterns of hepatic steatosis caused by the local effect of insulin revealed on chemical shift MR imaging. Am J Roentgenol. 2001;176:471–474
  70. Eisenberg LB, Warshauer DM, Woosley JT, et al. CT and MRI of hepatic focal nodular hyperplasia with peripheral steatosis. J Comput Assist Tomogr. 1995;19:498–500
  71. Kallio T, Nevalainen PI, Lahtela JT, Mustonen J, Pasternack A. Hepatic subcapsular steatosis in diabetic CAPD patients treated with intraperitoneal insulin. Description of a typical pattern. Acta Radiol. 2001;42:323–325
  72. Khalili K, Lan FP, Hanbidge AE, et al. Hepatic subcapsular steatosis in response to intraperitoneal insulin delivery: CT findings and prevalence. Am J Roentgenol. 2003;180:1601–1604
  73. Prasad SR, Wang H, Rosas H, et al. Fat-containing lesions of the liver: radiologic–pathologic correlation. Radiographics. 2005;25:321–331
  74. Mortele KJ, Stubbe J, Praet M, et al. Intratumoral steatosis in focal nodular hyperplasia coinciding with diffuse hepatic steatosis: CT and MRI findings with histologic correlation. Abdom Imaging. 2000;25:179–181
  75. Hamer OW, Aguirre DA, Casola G, Sirlin CB. Imaging features of perivascular fatty infiltration of the liver: initial observations. Radiology. 2005;237:159–169
  76. Salmonson EC, Lundstedt C, Holmin T, Hagerstrand I. Focal periportal liver steatosis. Abdom Imaging. 1993;18:39–41
  77. Yoon KH, Matsui O, Kadoya M, et al. Pseudolesion in segments II and III of the liver on CT during arterial portography caused by aberrant right gastric venous drainage. J Comput Assist Tomogr. 1999;23:306–309
  78. Aubin B, Denys A, Lafortune M, Dery R, Breton G. Focal sparing of liver parenchyma in steatosis: role of the gallbladder and its vessels. J Ultrasound Med. 1995;4:77–80
  79. Chong VF, Fan YF. Ultrasonographic hepatic pseudolesions: normal parenchyma mimicking mass lesions in fatty liver. Clin Radiol. 1994;49:326–329
  80. Tom WW, Yeh BM, Cheng JC, et al. Hepatic pseudotumor due to nodular fatty sparing: the diagnostic role of opposed-phase MRI. Am J Roentgenol. 2004;183:721–724
  81. Grossholz M, Terrier F, Rubbia L, et al. Focal sparing in the fatty liver as a sign of an adjacent space-occupying lesion. Am J Roentgenol. 1998;171:1391–1395
  82. Itai Y, Maeda M, Echigo J, et al. Hyperattenuating rim on noncontrast CT of the liver: probable peritumoral sparing of fatty infiltration. Clin Radiol. 1996;51:406–410
  83. Gabata T, Kadoya M, Matsui O, et al. Peritumoral spared area in fatty liver: correlation between opposed-phase gradient-echo MR imaging and CT arteriography. Abdom Imaging. 2001;26:384–389
  84. Chung JJ, Kim MJ, Kim JH, Lee JT, Yoo HS. Fat sparing of surrounding liver from metastasis in patients with fatty liver: MR imaging with histopathologic correlation. Am J Roentgenol. 2003;180:1347–1350
  85. Marti-Bonmati L, Penaloza F, Villarreal E, Martinez MJ. Nonspecificity of the fat-sparing ring surrounding focal liver lesion at MR imaging. Acad Radiol. 2005;12:1551–1556

PII: S0720-048X(06)00445-1

doi: 10.1016/j.ejrad.2006.11.005

European Journal of Radiology
Volume 61, Issue 1 , Pages 33-43 , January 2007