European Journal of Radiology
Volume 54, Issue 3 , Pages 352-358 , June 2005

Emphysematous changes and normal variation in smokers and COPD patients using diffusion 3He MRI

  • Andrew J. Swift

      Affiliations

    • Unit of Academic Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    • Corresponding Author InformationCorresponding author. Fax: +44 114 2724760.
    • ,
  • Jim M. Wild

      Affiliations

    • Unit of Academic Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    • ,
  • Stan Fichele

      Affiliations

    • Unit of Academic Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    • ,
  • Neil Woodhouse

      Affiliations

    • Unit of Academic Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    • ,
  • Sally Fleming

      Affiliations

    • Unit of Academic Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    • ,
  • Judith Waterhouse

      Affiliations

    • Department of Respiratory Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    • ,
  • Rod A. Lawson

      Affiliations

    • Department of Respiratory Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    • ,
  • Martyn N.J. Paley

      Affiliations

    • Unit of Academic Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    • ,
  • Edwin J.R. Van Beek

      Affiliations

    • Unit of Academic Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK

Received 10 May 2004 ,Revised 10 August 2004 ,Accepted 12 August 2004.

References 

  1. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet. 1997;349:1498–1504
  2. Sanders C, Nath PH, Biley WC. Detection of emphysema with computed tomography (Correlation with pulmonary function test and chest radiography). Invest Radiol. 1988;23:262
  3. Klein JS, Gamsu G, Webb WR, Golden JA, Muller ML. High-resolution CT diagnosis of emphysema in symptomatic patients with normal chest radiographs and isolated low diffusing capacity. Radiology. 1992;182:817–821
  4. Kauczor HU, Hofmann D, Kreitner KF, et al. Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging. Radiology. 1996;201:564–568
  5. MacFall JR, Charles HC, Black RD, et al. Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology. 1996;200:553–558
  6. Saam B, Yablonskiy DA, Kodibagkar VD, et al. MR imaging of diffusion of 3He gas in healthy and diseased lungs. Magn Reson Med. 2000;44:174–179
  7. Salerno M, De Lange EE, Altes TA, et al. Emphysema: hyperpolarized helium-3 diffusion MR imaging of the lungs compared with spirometric indexes—initial experience. Radiology. 2002;222(1):252–260
  8. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary). Am J Respir Crit Care Med. 2001;163:1256–1276
  9. De Lange EE, Mugler JP, Brookeman JR, et al. Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas. Radiology. 1999;210:851–857
  10. Schrieber WG, Bink A, Gast K, et al. Diffusion-weighted MRI of the lung using hyperpolarized helium-3. In: Helion 02. Oppenhiem, Germany. 2002;p. 36
  11. Chen XJ, Hedlund L, Moller HE, et al. Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. Proc Natl Acad Sci USA. 2000;97:11478–11481
  12. Madison JM, Irwin RS. Chronic obstructive pulmonary disease. Lancet. 1998;352(9126):467–473
  13. Brookeman JR, Mugler JP, Knight-Scott J, et al. Studies of 3He diffusion coefficient in the human lung: age-related distribution patterns. In: European Radiology B21 International Workshop. Les Houches, France. 1999;
  14. Gelb AF, Hogg JC, Muller NL, et al. Contribution of emphysema and small airways to COPD. Chest. 1996;109:353–359
  15. Gelb AF, Schein M, Kuei J, et al. Limited contribution of emphysema in advanced chronic obstructive pulmonary disease. Am Rev Respir Dis. 1993;147(5):1157–1161

PII: S0720-048X(04)00271-2

doi: 10.1016/j.ejrad.2004.08.002

European Journal of Radiology
Volume 54, Issue 3 , Pages 352-358 , June 2005

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