European Journal of Radiology
Volume 44, Issue 3 , Pages 172-181 , December 2002

MR imaging of lung cancer

  • Yoshiharu Ohno

      Affiliations

    • Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-78-382-6104; fax: +81-78-382-6129
  • ,
  • Kazuro Sugimura

      Affiliations

    • Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
  • ,
  • Hiroto Hatabu

      Affiliations

    • Pulmonary Functional Imaging, Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA

Received 5 September 2002 ,Revised 6 September 2002 ,Accepted 9 September 2002.

References 

  1. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics 2001. CA Cancer J. Clin. 2001;51:15–36
  2. Webb WR, Gatsonis C, Zerhouni EA, Heelan RT, Glazer GM, Francis IR, et al.  CT and MR imaging in staging non-small cell bronchogenic carcinoma: report of the Radiologic Diagnostic Oncology Group. Radiology. 1991;178:705–713
  3. Swensen SJ, Morin RL, Schueler BA, et al.  Solitary pulmonary nodule: CT evaluation of enhancement with iodinated contrast media—a preliminary report. Radiology. 1992;182:343–347
  4. Yamashita K, Matsnobe S, Tsuda T, et al.  Solitary pulmonary nodules: preliminary study of evaluation with incremental dynamic CT. Radiology. 1995;194:399–405
  5. Swensen SJ, Brown LR, Colby TV, Weaver AL, Midthum DE. Lung nodule enhancement at CT: prospective findings. Radiology. 1996;201:447–455
  6. Zhang M, Kono M. Solitary pulmonary nodules: evaluation of blood flow patterns with dynamic CT. Radiology. 1997;205:471–478
  7. Swensen SJ, Viggiano RW, Midthun DE, et al.  Lung nodule enhancement at CT: multicenter study. Radiology. 2000;214:73–80
  8. Patz EF, Lowe VJ, Hoffman JM, et al.  Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning. Radiology. 1993;188:487–490
  9. Dewan NA, Gupta NC, Redepenning LS, Phalen JJ, Frick MP. Diagnstic efficiency of PET-FDG imaging in solitary pulmonary nodules. Chest. 1993;104:997–1002
  10. Kusumoto M, Kono M, Adachi S, et al.  Gadopentetate dimeglumine-enhanced magnetic resonance imaging for lung nodules: differentiation of lung cancer and tuberculoma. Invest. Radiol. 1994;29:S255–S256
  11. Gückel C, Schnabel K, Deimling M, Steinbrich W. Solitary pulmonary nodules: MR evaluation of enhancement patterns with contrast-enhanced dynamic snapshot gradient-echo imaging. Radiology. 1996;200:681–686
  12. Kono M, Adachi S, Kusumoto M, Sakai E. Clinical utility of Gd–DTPA-enhanced magnetic resonance imaging in lung cancer. J. Thorac. Imaging. 1993;8:18–26
  13. White CS, Templeton PA, Belani CP. Imaging in lung cancer. Semin. Oncol. 1993;20:142–152
  14. Ohno Y, Hatabu H, Takenaka D, Adachi S, Kono M, Sugimura K. Solitary pulmonary nodules: potential role of dynamic MR imaging in management initial experience. Radiology. 2002;224:503–511
  15. Bourgouin PM, McLoud TC, Fitzgibbon JF, et al.  Differentiation of bronchogenic carcinoma from postobstructive pneumonitis by magnetic resonance imaging: histopathologic correlation. J. Thorac. Imaging. 1991;6:22–27
  16. Baron RL, Levitt RG, Sagel SS, White MJ, Roper CL, Marbarger JP. Computed tomography in the preoperative evaluation of bronchogenic carcinoma. Radiology. 1982;145:727–732
  17. Martini N, Heelan R, Westcott J, et al.  Comparative merits of conventional, computed tomographic, and magnetic resonance imaging in assessing mediastinal involvement in surgically confirmed lung carcinoma. J. Thorac. Cardiovasc. Surg. 1985;90:639–648
  18. Rendina EA, Bognolo DA, Mineo TC, et al.  Computed tomography for the evaluation of intrathoracic invasion by lung cancer. J. Thorac. Cardiovasc. Surg. 1987;94:57–63
  19. Herman SJ, Winton TL, Weisbrod GL, Towers MJ, Mentzer SJ. Mediastinal invasion by bronchogenic carcinoma: CT signs. Radiology. 1994;190:841–846
  20. Quint LE, Glazer GM, Orringer MB. Central lung masses: prediction with CT of need for pneumonectomy versus lobectomy. Radiology. 1987;165:735–738
  21. Quint LE, Francis IR, Wahl RL, Gross BH, Glazer GM. Preoperative staging of non-small-cell carcinoma of the lung: imaging methods. Am. J. Roentgenol. 1995;164:1349–1359
  22. Glazer HS, Kaiser LR, Anderson DJ, et al.  Indeterminate mediastinal invasion in bronchogenic carcinoma: CT evaluation. Radiology. 1989;173:37–42
  23. White PG, Adams H, Crane MD, Butchart EG. Preoperative staging of carcinoma of the bronchus: can computed tomographic scanning reliably identify stage III tumours?. Thorax. 1994;49:951–957
  24. Takahashi M, Shimoyama K, Murata K, et al.  Hilar and mediastinal invasion of bronchogenic carcinoma: evaluation by thin-section electron-beam computed tomography. J. Thorac. Imaging. 1997;12:195–199
  25. White CS. MR evaluation of the pericardium and cardiac malignancies. Magn. Resonance Imaging Clin. N. Am. 1996;4:237–251
  26. Wong J, Haramati LB, Rozenshtein A, Yanez M, Austin JH. Non-small-cell lung cancer: practice patterns of extrathoracic imaging. Acad. Radiol. 1999;6:211–215
  27. Takahashi K, Furuse M, Hanaoka H, et al.  Pulmonary vein and left atrial invasion by lung cancer: assessment by breath-hold gadolinium-enhanced three-dimensional MR angiography. J. Comput. Assist. Tomogr. 2000;24:557–561
  28. Ohno Y, Adachi S, Motoyama A, et al.  Multiphase ECG-triggered 3D contrast-enhanced MR angiography: utility for evaluation of hilar and mediastinal invasion of bronchogenic carcinoma. J. Magn. Resonance Imaging. 2001;13:215–224
  29. Mayr B, Heywang SH, Ingrisch H, Huber RM, Haussinger K, Lissner J. Comparison of CT with MR imaging of endobronchial tumors. J. Comput. Assist. Tomogr. 1987;11:43–48
  30. Magdeleinat P, Alifano M, Benbrahem C, et al.  Surgical treatment of lung cancer invading the chest wall: results and prognostic factors. Ann. Thorac. Surg. 2001;71:1094–1099
  31. Rapoport S, Blair DN, McCarthy SM, Desser TS, Hammers LW, Sostman HD. Brachial plexus: correlation of MR imaging with CT and pathologic findings. Radiology. 1988;167:161–165
  32. Padovani B, Mouroux J, Seksik L, et al.  Chest wall invasion by bronchogenic carcinoma: evaluation with MR imaging. Radiology. 1993;187:33–38
  33. Bonomo L, Ciccotosto C, Guidotti A, Storto ML. Lung cancer staging: the role of computed tomography and magnetic resonance imaging. Eur. J. Radiol. 1996;23:35–45
  34. Sakai S, Murayama S, Murakami J, Hashiguchi N, Masuda K. Bronchogenic carcinoma invasion of the chest wall: evaluation with dynamic cine MRI during breathing. J. Comput. Assist. Tomogr. 1997;21:595–600
  35. Freundlich IM, Chasen MH, Varma DG. Magnetic resonance imaging of pulmonary apical tumors. J. Thorac. Imaging. 1996;11:210–222
  36. Heelan RT, Demas BE, Caravelli JF, et al.  Superior sulcus tumors: CT and MR imaging. Radiology. 1989;170:637–641
  37. McLoud TC, Bourgouin PM, Greenberg RW, et al.  Bronchogenic carcinoma: analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling. Radiology. 1992;182:319–323
  38. Webb WR, Sarin M, Zerhouni EA, Heelan RT, Glazer GM, Gatsonis C. Interobserver variability in CT and MR staging of lung cancer. J. Comput. Assist. Tomogr. 1993;17:841–846
  39. Glazer GM, Orringer MB, Gross BH, Quint LE. The mediastinum in non-small cell lung cancer: CT-surgical correlation. Am. J. Roentgenol. 1984;142:1101–1105
  40. Musset D, Grenier P, Carette MF, et al.  Primary lung cancer staging: prospective comparative study of MR imaging with CT. Radiology. 1986;160:607–611
  41. Poon PY, Bronskill MJ, Henkelman RM, et al.  Mediastinal lymph node metastases from bronchogenic carcinoma: detection with MR imaging and CT. Radiology. 1987;162:651–656
  42. Laurent F, Drouillard J, Dorcier F, et al.  Bronchogenic carcinoma staging: CT versus MR imaging. Assessment with surgery. Eur. J. Cardiothorac. Surg. 1988;2:31–36
  43. Glazer GM, Gross BH, Aisen AM, Quint LE, Francis IR, Orringer MB. Imaging of the pulmonary hilum: a prospective comparative study in patients with lung cancer. Am. J. Roentgenol. 1985;145:245–248
  44. Stiglbauer R, Schurawitzki H, Klepetko W, et al.  Contrast-enhanced MRI for the staging of bronchogenic carcinoma: comparison with CT and histopathologic staging—preliminary results. Clin. Radiol. 1991;44:293–298
  45. Boiselle PM, Patz EF, Vining DJ, Weissleder R, Shepard JA, McLoud TC. Imaging of mediastinal lymph nodes: CT, MR, and FDG PET. Radiographics. 1998;18:1061–1069
  46. Gupta NC, Graeber GM, Bishop HA. Comparative efficacy of positron emission tomography with fluorodeoxyglucose in evaluation of small (<1 cm), intermediate (1–3 cm), and large (>3 cm) lymph node lesions. Chest. 2000;117:773–778
  47. Higashi K, Nishikawa T, Seki H, et al.  Comparison of fluorine-18-FDG PET and thallium-201 SPECT in evaluation of lung cancer. J. Nucl. Med. 1998;39:9–15
  48. Patz EF, Lowe VJ, Goodman PC, Herndon J. Thoracic nodal staging with PET imaging with 18FDG in patients with bronchogenic carcinoma. Chest. 1995;108:1617–1621
  49. Wahl RL, Quint LE, Greenough RL, Meyer CR, White RI, Orringer MB. Staging of mediastinal non-small cell lung cancer with FDG PET, CT, and fusion images: preliminary prospective evaluation. Radiology. 1994;191:371–377
  50. Patz EF, Lowe VJ, Hoffman JM, et al.  Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning. Radiology. 1993;188:487–490
  51. Dewan NA, Gupta NC, Redepenning LS, Phalen JJ, Frick MP. Diagnstic efficiency of PET-FDG imaging in solitary pulmonary nodules. Chest. 1993;104:997–1002
  52. Fujimoto K, Edamitsu O, Meno S, et al.  MR diagnosis for metastasis or non-metastasis of mediastinal and hilar lymph nodes in cases of primary lung cancer: detectability, signal intensity, and MR-pathologic correlation. Nippon Acta Radiol. 1995;55:162–171
  53. Walker R, Kessar P, Blanchard R, et al.  Turbo STIR magnetic resonance imaging as a whole-body screening tool for metastases in patients with breast carcinoma: preliminary clinical experience. J. Magn. Resonance Imaging. 2000;11:343–350
  54. Eustace S, Tello R, DeCarvalho V, Carey J, Melhem E, Yucel EK. Whole body turbo STIR MRI in unknown primary tumor detection. J. Magn. Resonance Imaging. 1998;8:751–753
  55. Takenaka D, Ohno Y, Hatabu H, et al.  Respiratory-triggered STIR turbo spin-echo imaging: potential role for management of mediatinal lymph nodes. Radiology. 2001;221:536
  56. Boland GW, Lee MJ, Gazelle GS, Halpern EF, McNicholas MM, Mueller PR. Characterization of adrenal masses using unenhanced CT: an analysis of the CT literature. Am. J. Roentgenol. 1998;171:201–204
  57. Szolar DH, Kammerhuber FH. Adrenal adenomas and nonadenomas: assessment of washout at delayed contrast-enhanced CT. Radiology. 1998;207:369–375
  58. Korobkin M, Lombardi TJ, Aisen AM, et al.  Characterization of adrenal masses with chemical shift and gadolinium-enhanced MR imaging. Radiology. 1995;197:411–418
  59. Hillers TK, Sauve MD, Guyatt GH. Analysis of published studies on the detection of extrathoracic metastases in patients presumed to have operable non-small cell lung cancer. Thorax. 1994;49:14–19
  60. Yokoi K, Kamiya N, Matsuguma H, et al.  Detection of brain metastasis in potentially operable non-small cell lung cancer: a comparison of CT and MRI. Chest. 1999;115:714–719
  61. Earnest F, Ryu JH, Miller GM, et al.  Suspected non-small cell lung cancer: incidence of occult brain and skeletal metastases and effectiveness of imaging for detection—pilot study. Radiology. 1999;21:137–145
  62. Eustace SJ, Walker R, Blake M, Yucel EK. Whole-body MR imaging. Practical issues, clinical applications, and future directions. Magn. Resonance Imaging Clin. N. Am. 1999;7:209–236
  63. Golebiowski A. Pulmonary resection in patients over 70 years old age. J. Thorac. Cardiovasc. Surg. 1971;61:265–270
  64. Legge JS, Palmer KNV. Pulmonary function in bronchial carcinoma. Thorax. 1973;28:588–591
  65. Imaeda T, Kanematu M, Asada S, et al.  Prediction of pulmonary function after resection of primary lung cancer: utility of inhalation–perfusion SPECT imaging. Clin. Nucl. Med. 1995;20:792–799
  66. Konietzko N. Nuclear medicine techniques in the management of bronchogenic carcinoma. Eur. J. Nucl. Med. 1987;13:S16–S19
  67. Hayes M, Taplin GV. Lung imaging with radioaerosols for the assessment of airway disease. Semin. Nucl. Med. 1980;10:243–251
  68. Young IR, Clarke GJ, Bailes DR, Pennock JM, Doyle FH, Bydder GM. Enhancement of relaxation rate with paramagnetic contrast agents in NMR imaging. J. Comput. Tomogr. 1981;5:543–546
  69. Pauling L, Coryell C. The magnetic properties and structure of the hemochromogens and related substances. Proc. Natl. Acad. Sci. USA. 1936;22:159–163
  70. Brooks RA, Chiro GD. Magnetic resonance imaging of stationary blood: a review. Med. Phys. 1987;14:905–913
  71. Thulborn KR, Brady TJ. Iron in magnetic resonance imaging of cerebral hemorrhage. Magn. Resonance Q. 1989;5:23–38
  72. Thulborn KR, Waterton JC, Matthew PW, et al.  Oxygenation dependence of transverse relaxation time of water protons in whole blood at high field. Biochem. Biophys. Acta. 1982;714:265–270
  73. Edelman RR, Hatabu H, Tadamura E, Li W, Prasad PV. Noninvasive assessment of regional ventilation in the human lung using oxygen-enhanced magnetic resonance imaging. Nat. Med. 1996;2:1236–1239
  74. Chen Q, Levin DL, Kim D, et al.  Pulmonary disorder: ventilation–perfusion MR imaging with animal models. Radiology. 1999;213:871–879
  75. Hatabu H, Chen Q, Levin DL, Tadamura E, Edelman RR. Ventilation–perfusion MR imaging of the lung. MRI Clin. N. Am. 1999;2:379–392
  76. Loffler R, Muller CJ, Peller M, Penzkofer H, Deimling M, Schwaiblmair M, et al.  Optimization and evaluation of the signal intensity change in multisection oxygen-enhanced MR lung imaging. Magn. Resonance Med. 2000;43:860–866
  77. Muller CJ, Schwaiblmair M, Scheidler J, Deimling M, Weber J, Loffler RB, et al.  Pulmonary diffusing capacity: assessment with oxygen-enhanced lung MR imaging preliminary findings. Radiology. 2002;222:499–506
  78. Ohno Y, Chen Q, Hatabu H. Oxygen-enhanced magnetic resonance ventilation imaging of lung. Eur. J. Radiol. 2001;37:164–171
  79. Hatabu H, Tadamura E, Chen Q, Stock KW, Li W, Prasad PV, et al.  Pulmonary ventilation: dynamic MRI with inhalation of molecular oxygen. Eur. J. Radiol. 2001;37:172–178
  80. Ohno Y, Hatabu H, Takenaka D, Adachi S, Van Cauteren M, Sugimura K. Oxygen-enhanced MR ventilation imaging of the lung: preliminary clinical experience in 25 subjects. Am. J. Roentgenol. 2001;177:185–194

PII: S0720-048X(02)00267-X

European Journal of Radiology
Volume 44, Issue 3 , Pages 172-181 , December 2002