European Journal of Radiology
Volume 44, Issue 2 , Pages 120-129 , November 2002

Neurological changes following radiation therapy for head and neck tumours

  • V.F.H Chong

      Affiliations

    • Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    • Corresponding Author InformationCorresponding author. Tel.: +65-326-5031; fax: +65-224-1407
  • ,
  • J.B.K Khoo

      Affiliations

    • Department of Diagnostic Radiology, National Cancer Centre, Singapore, Singapore
  • ,
  • L.L Chan

      Affiliations

    • Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
  • ,
  • H Rumpel

      Affiliations

    • Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore

Received 20 February 2002 ,Revised 22 February 2002 ,Accepted 25 February 2002.

References 

  1. Sheline GE, Wara WM, Smith V. Therapeutic irradiation and brain injury. Int. J. Radiat. Oncol. Biol. Phys. 1980;6:1215–1228
  2. Lee AWM, Law SCK, Ng SH, et al.  Retrospective analysis of nasopharyngeal carcinoma treated during1976–1985: late complications following megavoltage irradiation. Br. J. Radiol. 1992;65:918–928
  3. Qin D, Hu Y, Yan J, et al.  Analysis of 1379 patients with nasopharyngeal carcinoma treated by radiation. Cancer. 1988;61:1117–1124
  4. Lee AWN, Ng SH, Ho JHC, et al.  Clinical diagnosis of late temporal lobe necrosis following radiation therapy for nasopharyngeal carcinoma. Cancer. 1988;61:1535–1542
  5. Chong VFH, Fan YF. Radiation induced temporal lobe necrosis. Am. J. Neuroradiol. 1997;18:784–785
  6. Chong VFH, Fan YF, Chan LL. Temporal lobe necrosis in nasopharyngeal carcinoma. Australas. Radiol. 1997;41:392–397
  7. Chong VFH, Fan YF, Mukherji SK. Radiation-induced temporal lobe changes: CT and MR imaging characteristics. Am. J. Roentgenol. 2000;175:431–436
  8. Rabin BM, Meyer JR, Berlin JW, Marymount MH, Palka PS, Russell EJ. Radiation-induced changes in the central nervous system and head and neck. Radiographics. 1996;16:1055–1072
  9. Becker M, Schroth G, Zbaren P, et al.  Long-term changes induced by high dose irradiation of the head and neck region: imaging findings. Radiographics. 1997;17:5–26
  10. Rowley HA, Dillon WP. Iatrogenic white matter disease. Neuroimaging Clin. North Am. 1993;3:379–404
  11. Fajardo LP. Morphology of radiation effects on normal tissues. In:  Perez CA,  Brady LW editor. Principles and Practice of Radiation Oncology. Philadelphia: Lippincott; 1992;p. 114–123
  12. Mesic JB, Fletcher GH, Goepfert H. Megavoltage irradiation of epithelial tumors of the nasopharynx. Int. J. Radiat. Oncol. Biol. Phys. 1981;7:447–452
  13. Lee AWN, Yau TK. Complications of Radiotherapy. In:  Chong VFH,  Tsao SY editor. Nasopharyngeal Carcinoma. Singapore: Armour; 1997;p. 114–127
  14. Wara W, Phillips T, Sheline G, Schwade J. Radiation tolerance of the spinal cord. Cancer. 1975;35:1558–1562
  15. Ng SH, Wan YL, Ko SF, Chang JT. MRI of nasopharyngeal carcinoma with emphasis on relationship to radiotherapy. J. Magn. Reson. Imaging. 1998;8:327–336
  16. Flores AD, Dickson RI, Riding K, Coy P. Cancer of the nasopharynx in British Columbia. Am. J. Clin. Oncol. 1986;9:281–291
  17. Hoppe RT, Goffinet DR, Bagshaw MA. Carcinoma of the nasopharynx: 18 years’ experience with megavoltage radiation therapy. Cancer. 1976;37:2605–2612
  18. Chong VFH, Fan YF. Hypoglossal nerve palsy in nasopharyngeal carcinoma. Eur. Radiol. 1998;8:939–945
  19. Murakami R, Baba Y, Nishimura R, et al.  CT and MR findings of denervated tongue after neck dissection. Am. J. Neuroradiol. 1997;18:747–750
  20. Chong VFH, Rumpel H, Aw YS, Ho GL, Fan YF, Chua EJ. Temporal lobe necrosis following radiation therapy for nasopharyngeal carcinoma: proton MR spectroscopic findings. Int. J. Radiat. Oncol. Biol. Phys. 1999;45:699–705
  21. Usenius T, Usenius JP, Tenhunen M, et al.  Radiation-induced changes in human brain metabolites as studied by 1H nuclear magnetic resonance spectroscopy in vivo. Int. J. Radiat. Biol. Phys. 1995;33:719–724
  22. Waldrop SM, Davis PC, Padgett CA, Shapiro MB, Morris R. Treatment of brain tumors in children is associated with abnormal MR spectroscopic ratios in brain tissue remote from the tumor site. Am. J. Neuroradiol. 1998;19:963–970
  23. Chan YL, Yeung DKW, Leung SF, Cao G. Proton magnetic resonance spectroscopy of late delayed radiation-induced injury of the brain. J. Magn. Reson. Imaging. 1999;10:130–137
  24. Kahn D, Follett KA, Bushnell DL, et al.  Diagnosis of recurrent brain tumour: value of 201Tl SPECT vs 18F-fluorodeoxyglucose PET. Am. J. Roentgenol. 1994;163:1459–1465
  25. Chong VFH, Fan YF. Radiation induced temporal lobe necrosis. Am. J. Neuroradiol. 1997;18:784–785
  26. Chong VFH, Fan YF, Mukherji SK. Nasopharyngeal Carcinoma. Semin. Ultrasound CT MR. 1998;19:449–462

PII: S0720-048X(02)00066-9

European Journal of Radiology
Volume 44, Issue 2 , Pages 120-129 , November 2002