Differentiation of prostate cancer from benign prostate hypertrophy using dual-echo dynamic contrast MR imaging

Muramoto, Satoshi; Uematsu, Hidemasa; Kimura, Hirohiko; Ishimori, Yoshiyuki; Sadato, Norihiro; Oyama, Nobuyuki; Matsuda, Tsuyoshi; Kawamura, Yasutaka; Yonekura, Yoshiharu; Okada, Kenichiro; Itoh, Harumi

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Volume 44, Issue 1 , Pages 52-58, October 2002

Differentiation of prostate cancer from benign prostate hypertrophy using dual-echo dynamic contrast MR imaging

Satoshi Muramoto
- Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193, Japan
- Corresponding author. Tel.: +81-776-61-3111x2335; fax: +81-776-61-8137
Hidemasa Uematsu
- Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193, Japan
Hirohiko Kimura
- Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193, Japan
Yoshiyuki Ishimori
- Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193, Japan
Norihiro Sadato
- Psychophysiology Section, Department of Cerebral Research, National Institute for Physiological Sciences, Aichi, Japan
Nobuyuki Oyama
- Department of Urology, Fukui Medical University, Fukui, Japan
Tsuyoshi Matsuda
- Application Research Department, Advanced Technology Center, GE Yokogawa Medical Systems Ltd., Tokyo, Japan
Yasutaka Kawamura
- Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193, Japan
Yoshiharu Yonekura
- Biomedical Imaging Research Center, Fukui Medical University, Fukui, Japan
Kenichiro Okada
- Department of Urology, Fukui Medical University, Fukui, Japan
Harumi Itoh
- Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193, Japan

Received 5 November 2001; received in revised form 6 November 2001; accepted 7 November 2001.

Abstract

Objective: To investigate the usefulness of dynamic contrast magnetic resonance (MR) imaging in the differentiation of prostate cancer (PC) from benign prostate hypertrophy (BPH). Materials and methods: Eleven PC patients and 13 BPH patients were entered into the analysis. The mean gradient (MG) was calculated from the T2* term-eliminated time-signal intensity curve obtained from dynamic contrast MR data, and the MG of PC and that of BPH were compared. Results: The MG of PC was significantly higher than that of BPH. When the threshold value was set to 1.88% per s for discriminating PC from BPH, the sensitivity, specificity, and accuracy were 100, 85, and 92%, respectively. Conclusion: The MG, which is derived from the T2* term-eliminated time-signal intensity curve, may be a useful index for differentiating PC from BPH.

Keywords: MR-imaging, Urinary, Prostate, Neoplasms-primary, Tissue characterization