European Journal of Radiology
Volume 41, Issue 3 , Pages 192-199 , March 2002

Initial observations on the effect of irradiation on the liver-specific uptake of Levovist

  • Emilio Quaia

      Affiliations

    • Department of Radiology, Imperial College School of Medicine (Hammersmith Hospital Campus), Du Cane Road, London W12 0NN, UK
    • Department Radiology, Trieste University Hospital, Trieste, Italy
  • ,
  • Martin J.K Blomley

      Affiliations

    • Department of Radiology, Imperial College School of Medicine (Hammersmith Hospital Campus), Du Cane Road, London W12 0NN, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44-20-8-3831023; fax: +44-20-8-1700
  • ,
  • Shetal Patel

      Affiliations

    • Department of Radiology, Imperial College School of Medicine (Hammersmith Hospital Campus), Du Cane Road, London W12 0NN, UK
  • ,
  • Christopher J Harvey

      Affiliations

    • Department of Radiology, Imperial College School of Medicine (Hammersmith Hospital Campus), Du Cane Road, London W12 0NN, UK
  • ,
  • Anwar Padhani

      Affiliations

    • Paul Strickland Scanner Centre, Mount Vernon Hospital, Ricksmansworth Road, Northwood, Middlesex, London HA6 2RN, UK
  • ,
  • Pat Price

      Affiliations

    • MRC PET Oncology Group, Imperial College School of Medicine (Hammersmith Hospital Campus), Du Cane Road, London W12 0NN, UK
  • ,
  • David O Cosgrove

      Affiliations

    • Department of Radiology, Imperial College School of Medicine (Hammersmith Hospital Campus), Du Cane Road, London W12 0NN, UK

Received 15 October 2001 ,Revised 17 October 2001 ,Accepted 18 October 2001.

References 

  1. Blomley MJK, Cooke JC, Unger EC, Monaghan MJ, Cosgove DO. Microbubble contrast agents: a new era in ultrasound. Br. Med. J. 2001;322:1222–1225
  2. Blomley MJK, Albrecht T, Cosgrove DO, et al.  Stimulated acoustic emission in the liver parenchyma with Levovist. Lancet. 1998;351:568
  3. Schneider M, Broillet A, Bussat P, et al.  Grey scale liver enhancement in VX2 tumor bearing rabbits using BR14, a new ultrasonographic contrast agent. Invest. Radiol. 1997;32:410–417
  4. Blomley MJK, Albrecht T, Cosgrove DO, et al.  Stimulated acoustic emission to image a late liver and spleen specific phase of Levovist in normal volunteers and patients with and without liver disease. Ultrasound. Med. Biol. 1999;25:1341–1352
  5. Hauff P, Fritzsch T, Reinhardt M, et al.  Delineation of experimental liver tumors in rabbits by a new ultrasound contrast agent and stimulated acoustic emission. Invest. Radiol. 1997;32:94–99
  6. Forsberg F, Goldberg BB, Liu JB, et al.  Tissue specific US contrast agent for evaluation of hepatic and splenic parenchyma. Radiology. 1999;210:125–132
  7. Albrecht T, Hoffmann CW, Schmitz SA, et al.  Phase inversion sonography during the liver specific phase of contrast enhancement: improved detection of liver metastases. Am. J. Roentgenol. 2001;176:1191–1198
  8. Dalla Palma L, Bertolotto M, Quaia E, Locatelli M. Detection of liver metastases with pulse inversion harmonic imaging: preliminary results.. Eur. Radiol. 1999;9(Suppl. 3):S382–S387
  9. Harvey CJ, Blomley MJ, Eckersley RJ, et al.  Hepatic malignancies: improved detection with pulse inversion US in late phase of enhancement with SH U 508 A—early experience. Radiology. 2000;216:903–908
  10. Clement O, Muhler A, Vexler V, et al.  Evaluation of radiation induced liver injury with MR imaging: comparison of hepatocellular and reticuloendothelial contrast agents. Radiology. 1992;185:163–168
  11. Padhani AR, Husband JE, Gueret Wardle D. Radiation induced liver injury detected by particulate reticuloendothelial contrast agent. Br. J. Radiol. 1998;71:1089–1092
  12. Benacerraf B, Kivy-Rosemberg E, Sebestyen MM, Zweifach BW. The effect of high doses of x-irradiation on the phagocytic, proliferative and metabolic properties of the reticulo-endothelial system. J. Exp. Med. 1959;110:49–64
  13. Hebard DW, Jackson KL, Christenson GM. The chronological development of late radiation injury in the liver of the rat. Radiat. Res. 1980;81:441–454
  14. Gelfand MJ, Saha S, Aron BS. Imaging of irradiated liver with Tc-99m-sulfur colloid and Tc-99m-IDA. Clin. Nucl. Med. 1981;6:399
  15. Kurohara SS, Swensson NL, Usselman JA, George FR. Response and recovery of liver to radiation as demonstrated by photoscan. Radiology. 1967;89:129–133
  16. Garra BS, Shawker TH, Chang R, et al.  The ultrasound appearance of radiation-induced hepatic injury: correlation with computed tomography and magnetic resonance imaging. J. Ultrasound. Med. 1988;7:605–609
  17. Unger EC, Lee JK, Weyman PJ. CT and MR imaging of radiation hepatitis. J. Comput. Assist. Tomogr. 1987;11:264–268
  18. Bismuth H. Surgical anatomy and anatomical surgery of the liver. World J. Surg. 1982;6:3–8
  19. Coinaud C. In: Le foie: etudes anatomiques et chirurgicales. Paris, France: Masson; 1957;p. 9–12
  20. Lawrence TS, Robertson JM, Anscher MS, et al.  Hepatic toxicity resulting from cancer treatment. Int. J. Radiat. Oncol. Biol. Phys. 1995;31:1237–1248
  21. Masui T, Yan H, Kosugi I, et al.  Assessment of early radiation effects on the liver. Comparison of SPECT and MR. Acta Radiol. 1996;37:665–671

PII: S0720-048X(01)00458-2

European Journal of Radiology
Volume 41, Issue 3 , Pages 192-199 , March 2002