European Journal of Radiology
Volume 41, Issue 3 , Pages 200-206 , March 2002

Multi-centre clinical study evaluating the efficacy of SonoVue™ (BR1), a new ultrasound contrast agent in Doppler investigation of focal hepatic lesions

  • E Leen

      Affiliations

    • Radiology Department, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44-141-211-4002; fax: +44-141-211-4781
    • gpda01@udcf.gla.ac.uk.
    • ,
  • W.J Angerson

      Affiliations

    • Radiology Department, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    • ,
  • S Yarmenitis

      Affiliations

    • Radiology Department, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    • ,
  • G Bongartz

      Affiliations

    • Division of General Radiology, Poliklinik Basel, Basel, Switzerland
    • ,
  • M Blomley

      Affiliations

    • Department of Imaging, Hammersmith Hospital, London, UK
    • ,
  • A Del Maschio

      Affiliations

    • Instituto di Radiologia, Ospedale San Raffaele, Milan, Italy
    • ,
  • V Summaria

      Affiliations

    • Instituto di Radiologia, Università Cattolica Sacro Cuore, Largo A, Rome, Italy
    • ,
  • G Maresca

      Affiliations

    • Instituto di Radiologia, Università Cattolica Sacro Cuore, Largo A, Rome, Italy
    • ,
  • C Pezzoli

      Affiliations

    • Bracco Imaging, Milan, Italy
    • ,
  • J.B Llull

      Affiliations

    • Bracco, Geneva, Switzerland

Received 15 October 2001 ,Revised 17 October 2001 ,Accepted 18 October 2001.

References 

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  2. Veltri A, Capello S, Faissola B, et al.  Dynamic contrast enhanced ultrasound with carbon dioxide as an adjunct to arteriography of liver tumours. Cardiovasc. Intervent. Radiol. 1994;17:133–137
  3. Kudo M, Tomita S, Tochio H, et al.  Small hepatocellular carcinoma: diagnosis with US angiography with intraarterial CO2 microbubbles. Radiology. 1992;182:155–160
  4. Hashimoto M, Watanabe O, Hirano Y, Kato K, Watarai J. Use of carbon dioxide microbubble enhanced sonographic angiography for transcatheter arterial chemoembolisation of hepatocellular carcinoma. Am. J. Roentgenol. 1997;169:1307–1310
  5. Solbiati L, Goldberg SN, Ierace T, Dellanoce M, Livraghi T, Gazelle GS. Radio-frequency ablation of hepatic metastases: post procedural assessment with a US microbubble contrast agent: early experience. Radiology. 1999;211(3):643–649
  6. Schneider M, Arditi M, Barrau M, Brochot J, Broillet A, Ventrone R, et al. BRI: a new ultrasonographic contrast agent based on sulfur hexafluoride-filled microbubbles. Invest. Radiol. 1995;30:451–457
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  8. Leen E, Angerson WG, Warren H, et al.  Improved colour Doppler flow imaging of colorectal hepatic metastases using galactose microparticles: a preliminary report. Br. J. Surg. 1994;81:252–254
  9. Angeli E, Carpanelli R, Crespi G, et al.  Efficacy of SH U 508 A in colour Doppler ultrasonography of hepatocellular carcinoma vascularisation. Radiol. Med. Torino (Suppl.). 1994;87:24–31
  10. Maresca G, Barbaro B, Summaria V, et al.  Colour Doppler ultrasonography in the differential diagnosis of focal hepatic lesions: The SH U 508 A experience. Radiol. Med. Torino (Suppl.). 1994;87:41–49
  11. Tano S, Ueno N, Tomiyama T, et al.  Possibility of differentiating small hyperechoic liver tumours using contrast enhanced colour Doppler ultrasonography: a preliminary study. Clin. Radiol. 1997;52:41–45
  12. Tanaka S, Kitamra T, Yoshioka F, et al.  Effectiveness of galactose based intravenous contrast medium on colour Doppler sonography of deeply located hepatocellular carcinoma. Ultrasound. Med. Biol. 1995;21:157–160
  13. Ramnarine K, Leen E, Oppo K, et al.  Improved characterisation of focal liver of focal liver tumours: dynamic power Doppler imaging using NC 100100 echo-enhancer. Eur. J. Ultrasound. 2000;11(2):95–104

PII: S0720-048X(01)00457-0

European Journal of Radiology
Volume 41, Issue 3 , Pages 200-206 , March 2002

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