European Journal of Radiology
Volume 40, Issue 1 , Pages 33-44 , October 2001

Hyperpolarized noble gas MR imaging of the lung: Potential clinical applications

  • Michael Salerno

      Affiliations

    • Department of Radiology, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    • Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    • ,
  • Talissa A Altes

      Affiliations

    • Department of Radiology, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    • ,
  • John P Mugler III

      Affiliations

    • Department of Radiology, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    • ,
  • Masashi Nakatsu

      Affiliations

    • Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    • ,
  • Hiroto Hatabu

      Affiliations

    • Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    • ,
  • Eduard E de Lange

      Affiliations

    • Department of Radiology, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    • Corresponding Author InformationCorresponding author

Received 20 April 2001 ,Revised 23 April 2001 ,Accepted 25 April 2001.

References 

  1. Middleton H, Black RD, Saam B, et al.  MR imaging with hyperpolarized He-3 gas. Magn. Reson. Med. 1995;33:271–275
  2. Black RD, Middleton HL, Cates GD, et al.  In vivo He-3 MR images of guinea pig lungs. Radiology. 1996;199:867–870
  3. Kauczor HU, Hofmann D, Kreitner KF, et al.  Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging. Radiology. 1996;201:564–568
  4. MacFall JR, Charles HC, Black RD, et al.  Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology. 1996;200:553–558
  5. Kauczor HU, Ebert M, Kreitner KF, et al.  Imaging of the lungs using 3He MRI: preliminary clinical experience in 18 patients with and without lung disease. J. Magn. Reson. Imaging. 1997;7:538–543
  6. de Lange EE, Mugler JP, Brookeman JR, et al.  Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas. Radiology. 1999;210:851–857
  7. Altes TA, Powers PL, Knight-Scott J, et al.  Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings. J. Magn. Reson. Imaging. 2001;13:378–384
  8. Donnelly LF, MacFall JR, McAdams HP, et al.  Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung — preliminary observations. Radiology. 1999;212:885–889
  9. Ruppert K, Brookeman JR, Hagspiel KD, Mugler JP. Probing lung physiology with xenon polarization transfer contrast (XTC). Magn. Reson. Med. 2000;44:349–357
  10. Ruppert K, Brookeman JR, Hagspiel KD, Driehuys B, Mugler JP. NMR of hyperpolarized 129Xe in the canine chest: spectral dynamics during a breath-hold. NMR Biomed. 2000;13(4):220–228
  11. Happer W, Miron E, Schaefer S, Schreiber D, van Wijngaarden WA, Zeng X. Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms. Phys. Rev. A. 1984;29:3092–3110
  12. Eckert G, Heil W, Meyerhoff M, et al.  A dense polarized 3He target based on compression of optically pumped gas. Nucl. Inst. Meth. Phys. Res. A. 1992;320:53–65
  13. Becker J, Heil W, Krug B, et al.  Study of mechanical compression of spin-polarized 3He gas. Nucl. Inst. Meth. Phys. Res. A. 1994;346:45–51
  14. Becker J, Bermuth J, Ebert M, et al.  Interdisciplinary experiments with polarized He-3. Nucl. Inst. Meth. Phys. Res. A. 1998;402:327–336
  15. Bachert P, Schad LR, Bock M, Knopp MV, Ebert M, Grossmann T, et al. Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized 3He. Magn. Reson. Med. 1996;36:192–196
  16. Mata J, Altes T, Christopher J, Mugler JP, Brookeman JR, de Lange EE. Positional dependence of small inferior ventilation defects seen on hyperpolarized helium-3 MR of the lung. In: Proc Int Soc Magn Reson Med, 9th Meeting, 2001.
  17. Kauczor H, Surkau R, Roberts T. MRI using hyperpolarized noble gases. Eur. Radiol. 1998;8:820–827
  18. Guenther D, Eberle B, Hast J, Lill J, Markstaller K, Puderbach M, et al. 3He MRI in healthy volunteers: preliminary correlation with smoking history and lung volumes. NMR Biomed. 2000;13:182–189
  19. Altes T, Froh DK, Salerno M, Cook CD, Mata J, Mugler III JP, de Lange EE, Brookemam JR. Hyperpolarized helium-3 MR imaging of lung ventilation changes following airway mucus clearance treatment in cystic fibrosis. In: Proc Int Soc Magn Reson Med, 9th Meeting, 2001.
  20. Williams MT. Chest physiotherapy and cystic fibrosis: why is the most effective form of treatment still unclear?. Chest. 1994;106:1872–1882
  21. McAdams HP, Palmer SM, Donnelly LF, Charles HC, Tapson VF, MacFall JR. Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results. Am. J. Roentgenol. 1999;173:955–959
  22. Chen XJ, Helund LW, Chawla MS, Moller HE, Johnson GA. Detection of elastase-induced emphysema in rat lungs by measuring diffusion of hyperpolarized 3He. In: Proc Int Soc Magn Reson Med, 7th Meeting, 1999, p. 130.
  23. Mugler III JP, Brookeman JR, Knight-Scott J, Maier T, de Lange EE, Bogorad PL. Regional measurement of the 3He diffusion coefficient in the human lung. In: Proc Int Soc Magn Reson Med, 6th Meeting, 1998, p. 1906.
  24. Salerno M, Brookeman JR, de Lange EE, Knight-Scott J, Mugler III JP. Demonstration of an alveolar-size gradient in the healthy human lung: a study of the reproducibility of hyperpolarizd 3He diffusion MRI. In: Proc Int Soc Magn Reson Med, 8th Meeting, 2000, p. 2195.
  25. Saam B, Yablonskiy DA, Gierada DS, Cooper JD, Conradi MS. Measurements of 3He diffusivity in human lung: preliminary results from an emphysema patient. In: Proc Int Soc Magn Reson Med, 7th Meeting, 1999, p. 136.
  26. Salerno M, Brookeman JR, de Lange EE, Knight-Scott J, Mugler III JP. Detection of regional microstructural changes of the lung in emphysema using hyperpolarized 3He diffusion MRI. In: Proc Int Soc Magn Reson Med, 8th Meeting, 2000, p. 9.
  27. Saam BT, Yablonskiy DA, Kodibagkar VD, et al.  MR imaging of diffusion of 3He gas in healthy and diseased lungs. Magn. Reson. Med. 2000;44:174–179
  28. Salerno M, de Lange EE, Altes TA, Truwit JD, Brookeman JR, Mugler III JP. Hyperpolarized 3He diffusion MRI of the lungs in emphysema: a comparison with pulmonary function tests. Initial experience. Radiology 2001, in press.
  29. Roberts TPL, Surkau R, Kauczor HU, Kreitner KF, Grossmann T, Hofmann D, Ebert M, Otten E, Thelen M. Helium-3 MRI of lung ventilatory function. In: Proc Int Soc Magn Reson Med, 5th Meeting, 1997, p. 307.
  30. Schreiber WG, Markstaller K, Kauczor HU, Surkau R, Eberle B, Grossmann T, Weiler N, Otten E, Thelen M. Ultrafast imaging of lung ventilation using hyperpolarized helium-3. In: Proc Int Soc Magn Reson Med, 7th Meeting, 1999, p. 129.
  31. Ruppert K, Brookeman JR, Mugler III JP. Real-time MR imaging of pulmonary gas-flow dynamics with hyperpolarized 3He. In: Proc Int Soc Magn Reson Med, 6th Meeting, 1998, p. 1909.
  32. Saam B, Yablonskiy DA, Gierada DS, Conradi MS. Rapid imaging of hyperpolarized gas using EPI. Magn. Reson. Med. 1999;42:507–514
  33. Gierada DS, Saam B, Yablonskiy D, Cooper JD, Lefrak SS, Conradi MS. Dynamic echo planar MR imaging of lung ventilation with hyperpolarized 3He in normal subjects and patients with severe emphysema. NMR Biomed. 2000;13:176–181
  34. Mugler III JP, Brookeman JR, Knight-Scott J, Maier T, de Lange EE, Bogorad PL. Interleaved echo-planar imaging of the lungs with hyperpolarized 3He. In: Proc Int Soc Magn Reson Med, 6th Meeting, 1998, p. 448.
  35. Chen XJ, Chawla MS, Hedlund LW, Möller HE, MacFall JR, Johnson GA. MR microscopy of lung airways with hyperpolarized 3He. Magn. Reson. Med. 1998;39:79–84
  36. Viallon M, Berthezene Y, Callot V, Bourgeois M, Humblot H, Briguet A, et al. Dynamic imaging of hyperpolarized 3He distribution in rat lungs using interleaved-spiral scans. NMR Biomed. 2000;13:207–213
  37. Roberts DA, Rizi RR, Lipson DA, Aranda M, Baumgardner J, Bearn L, et al. Detection and localization of pulmonary air leaks using laser-polarized 3He MRI. Magn. Reson. Med. 2000;44:379–382
  38. Salerno M, Altes TA, Brookeman JR, de Lange EE, Mugler III JP. Dynamic Spiral MR Imaging of Pulmonary Gas Flow Using Hyperpolarized 3He: Preliminary Studies In Healthy and Diseased Lungs. Magn Reson Med 2001;46:667–77.
  39. Reiderer SJ, Tasciyan T, Farzaneh F, Lee JN, Wright RC, Herfkens RJ. MR fluoroscopy: technical feasibility. Magn. Reson. Med. 1988;8:1–15
  40. Spielman DM, Pauly JM, Meyer CH. Magnetic resonance fluoroscopy using spirals with variable sampling densities. Magn. Reson. Med. 1995;34:388–394
  41. Spielman DM, Pauly JM, Meyer CH. Magnetic resonance fluoroscopy using spirals with variable sampling densities. Magn. Reson. Med. 1995;34:388–394
  42. Saam B, Happer W, Middleton H. Nuclear relaxation of 3He in the presence of O2. Phys. Rev. A. 1995;52:862–865
  43. Deninger AJ, Eberle B, Ebert M, Großmann T, Heil W, Kauczor H, et al. Quantification of regional intrapulmonary oxygen partial pressure evolution during apnea by 3He MRI. J. Magn. Reson. 1999;141:207–216
  44. Eberle B, Weiler N, Markstaller K, Kauczor H, Deninger A, Ebert M, et al. Analysis of intrapulmonary O2 concentration by MR imaging of inhaled hyperpolarized helium-3. J. Appl. Physiol. 1999;87:2043–2052
  45. Deninger AJ, Eberle B, Ebert M, Großmann T, Hanisch G, Heil W, et al. 3He-MRI-based measurements of intrapulmonary PO2 and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations. NMR Biomed. 2000;13:194–201

PII: S0720-048X(01)00347-3

European Journal of Radiology
Volume 40, Issue 1 , Pages 33-44 , October 2001

Article Tools

* Image Usage & Resolution